{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:11:54Z","timestamp":1784214714169,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K1923481"],"award-info":[{"award-number":["K1923481"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K2022971"],"award-info":[{"award-number":["K2022971"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K2111151"],"award-info":[{"award-number":["K2111151"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K2211921"],"award-info":[{"award-number":["K2211921"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K2225581"],"award-info":[{"award-number":["K2225581"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K2512341"],"award-info":[{"award-number":["K2512341"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence regarding the risk\u2010stratified effectiveness of drug\u2010coated balloon (DCB)\u2010based PCI for de novo coronary artery disease (CAD) remains limited, particularly in patients undergoing complex and high\u2010risk indicated percutaneous coronary intervention (CHIP PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of DCB\u2010based PCI versus DES\u2010only PCI for de novo CAD across CHIP risk categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients treated with DCB alone or with a hybrid DCB\/drug\u2010eluting stent (DES) strategy between 2010 and 2023 were retrospectively analyzed (DCB\u2010based group). The comparator group included patients treated exclusively with second\u2010generation DES from a Korean multicenter registry. The primary endpoint was the 2\u2010year incidence of major adverse cardiovascular events (MACE): cardiac death, myocardial infarction, target vessel revascularization (TVR), target lesion thrombosis, and major bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Total 2022 propensity score\u2010matched pairs were stratified by CHIP score into low (0\u20132; 1660 pairs), intermediate (3\u20134; 304 pairs), and high (\u2265\u20095; 91 pairs) risk groups. DCB\u2010only treatment accounted for 70.8% of the DCB\u2010based group, with hybrid approaches more frequent in higher\u2010risk patients. Two\u2010year MACE rates increased with CHIP risk in both groups, but remained consistently lower in the DCB\u2010based group: 5.3%, 6.3%, and 20.0% versus 10.9%, 16.9%, and 31.2% for DES\u2010only PCI (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). DCB\u2010based PCI was associated with lower MACE risk across all CHIP categories (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with no significant interaction (p\u2010interaction\u2009=\u20090.819). TVR reduction was significant in the low\u2010to\u2010intermediate risk (p\u2010interaction\u2009=\u20090.056), and major bleeding declined with increasing CHIP risk, most notably in the high\u2010risk group (p\u2010interaction\u2009=\u20090.044).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DCB\u2010based PCI was associated with significantly lower 2\u2010year MACE rates across all CHIP risk categories and may offer a potential alternative to DES\u2010only strategies in selective patients.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical trial registration number<\/jats:bold>\n                      REAL\u2010DCB registry (NCT04619277), PTRG\u2010DES registry (NCT04734028).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70756","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:55:44Z","timestamp":1784213744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Coated Balloon\u2010Based Strategy for De Novo Coronary Artery Disease Across Complex and High\u2010Risk Indicated Percutaneous Coronary Intervention Risk Categories: A Multicenter Registry Study"],"prefix":"10.1002","author":[{"given":"Dong Oh","family":"Kang","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Korea University Ansan Hospital, Korea University College of Medicine  Ansan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae\u2010Young","family":"Her","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Kangwon National University School of Medicine  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-6968","authenticated-orcid":false,"given":"Eun\u2010Seok","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ulsan University Hospital, University of Ulsan College of Medicine  Ulsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"12","key":"e_1_2_10_2_1","first-page":"1391","article-title":"Drug\u2010Coated Balloons for Coronary Artery Disease","volume":"13","author":"Jeger R. 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Y.","year":"2025","journal-title":"JACC: Asia"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.54912\/jci.2024.0019","article-title":"Drug\u2010Coated Balloon\u2010Based Percutaneous Coronary Intervention in De Novo Coronary Artery Disease and Tips for Procedural Success","volume":"3","author":"Kim S.","year":"2024","journal-title":"Journal of Cardiovascular Intervention"},{"issue":"2","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/jamacardio.2024.4244","article-title":"Drug\u2010Coated Balloons for the Treatment of Coronary Artery Disease: A Review","volume":"10","author":"Camaj A.","year":"2025","journal-title":"JAMA Cardiology"},{"issue":"3","key":"e_1_2_10_6_1","first-page":"292","article-title":"Clinical Impact of Drug\u2010Coated Balloon\u2010Based Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease","volume":"16","author":"Shin E. S.","year":"2023","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"7","key":"e_1_2_10_7_1","first-page":"519","article-title":"Drug\u2010Coated Balloon Angioplasty in Patients Undergoing Complex Percutaneous Coronary Intervention","volume":"4","author":"Joh H. S.","year":"2024","journal-title":"JACC: Asia"},{"issue":"2","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tcm.2024.08.006","article-title":"Coronary Drug\u2010Coated Balloons: A Comprehensive Review of Clinical Applications and Controversies","volume":"35","author":"Khawaja M.","year":"2025","journal-title":"Trends in Cardiovascular Medicine"},{"issue":"5","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/CIRCULATIONAHA.116.022061","article-title":"Treatment of Higher\u2010Risk Patients With an Indication for Revascularization: Evolution Within the Field of Contemporary Percutaneous Coronary Intervention","volume":"134","author":"Kirtane A. J.","year":"2016","journal-title":"Circulation"},{"issue":"1","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jcin.2021.09.039","article-title":"Defining Percutaneous Coronary Intervention Complexity and Risk: An Analysis of the United Kingdom BCIS Database 2006\u22122016","volume":"15","author":"Protty M.","year":"2022","journal-title":"JACC. Cardiovascular interventions"},{"issue":"1","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.5603\/CJ.a2019.0093","article-title":"Drug\u2010Coated Balloon Treatment in Coronary Artery Disease: Recommendations From an Asia\u2010Pacific Consensus Group","volume":"28","author":"Her A. 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A.","year":"2014","journal-title":"Nature Reviews Cardiology"},{"issue":"41","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1093\/eurheartj\/ehad215","article-title":"Redefining the Way to Perform Percutaneous Coronary Intervention: A View in Search of Evidence","volume":"44","author":"Colombo A.","year":"2023","journal-title":"European Heart Journal"},{"issue":"2","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/jcm11020299","article-title":"Favorable Vasomotor Function After Drug\u2010Coated Balloon\u2010Only Angioplasty of De Novo Native Coronary Artery Lesions","volume":"11","author":"Kim S.","year":"2022","journal-title":"Journal of Clinical Medicine"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijcard.2020.07.028","article-title":"Possible Mechanism of Late Lumen Enlargement After Treatment for De Novo Coronary Lesions With Drug\u2010Coated Balloon","volume":"321","author":"Yamamoto T.","year":"2020","journal-title":"International Journal of Cardiology"},{"issue":"13","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"e818","DOI":"10.4244\/EIJ-D-23-01006","article-title":"Predictors of Target Lesion Failure After Percutaneous Coronary Intervention With a Drug\u2010Coated Balloon for De Novo Lesions","volume":"20","author":"Lee T.","year":"2024","journal-title":"EuroIntervention"},{"issue":"1","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1038\/s41598-025-92052-2","article-title":"Predictors of Optimal Angiographic Lesion Outcomes in Drug\u2010Coated Balloon Treatment for De Novo Coronary Artery Disease","volume":"15","author":"Kang D. O.","year":"2025","journal-title":"Scientific Reports"},{"issue":"10150","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(18)31719-7","article-title":"Drug\u2010Coated Balloons for Small Coronary Artery Disease (Basket\u2010Small 2): An Open\u2010Label Randomised Non\u2010Inferiority Trial","volume":"392","author":"Jeger R. V.","year":"2018","journal-title":"Lancet"},{"issue":"10194","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(19)31126-2","article-title":"Drug\u2010Coated Balloon for Treatment of De\u2010Novo Coronary Artery Lesions in Patients With High Bleeding Risk (DEBUT): A Single\u2010Blind, Randomised, Non\u2010Inferiority Trial","volume":"394","author":"Rissanen T. T.","year":"2019","journal-title":"The Lancet"},{"issue":"10457","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S0140-6736(24)01594-0","article-title":"Drug\u2010Coated Balloon Angioplasty With Rescue Stenting Versus Intended Stenting for the Treatment of Patients With De Novo Coronary Artery Lesions (REC\u2010CAGEFREE I): an Open\u2010Label, Randomised, Non\u2010Inferiority Trial","volume":"404","author":"Gao C.","year":"2024","journal-title":"Lancet"},{"issue":"13","key":"e_1_2_10_26_1","first-page":"1519","article-title":"Intravascular Ultrasound Vs Angiography\u2010Guided Drug\u2010Coated Balloon Angioplasty","volume":"17","author":"Gao X. F.","year":"2024","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"17","key":"e_1_2_10_27_1","first-page":"1691","article-title":"Paclitaxel\u2010Coated Balloon Angioplasty Versus Drug\u2010Eluting Stent in Acute Myocardial Infarction","volume":"12","author":"Vos N. S.","year":"2019","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"1","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-75201-x","article-title":"Long\u2010Term Efficacy of Drug\u2010Coated Balloon\u2010Based Treatment for De Novo Left Anterior Descending Artery Disease","volume":"14","author":"Kang D. O.","year":"2024","journal-title":"Scientific Reports"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2026.134621","article-title":"Drug\u2010Coated Balloon Versus Drug\u2010Eluting Stent for Isolated Ostial Side\u2010Branch Bifurcation (Medina 0.0.1) Lesions","volume":"460","author":"Kang D. O.","year":"2026","journal-title":"International Journal of Cardiology"},{"issue":"9","key":"e_1_2_10_30_1","first-page":"1011","article-title":"Validation of UK\u2010BCIS CHIP Score to Predict 1\u2010Year Outcomes in a Contemporary United States Population","volume":"16","author":"Khandelwal G.","year":"2023","journal-title":"JACC: Cardiovascular Interventions"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:55:49Z","timestamp":1784213749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":29,"alternative-id":["10.1002\/ccd.70756"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70756","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"2026-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ccd.70756"}}