{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:00:17Z","timestamp":1785286817958,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Imaging\u2010guided percutaneous coronary intervention (PCI) improves outcomes, but the clinical utility of near\u2010infrared spectroscopy (NIRS) remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n The aim of the study was to evaluate whether multimodality imaging with NIRS, intravascular ultrasound (IVUS) and optical coherence tomography (OCT) would improve stent strut coverage compared with angiography\u2010guided PCI in patients with acute myocardial infarction (MI) and further to assess the impact of lipid\u2010rich plaque (LRP) on vascular healing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 104 patients with MI were randomized to imaging\u2010 or angiography\u2010guided PCI. NIRS\u2010IVUS imaging was performed pre\u2010 and post\u2010PCI, and OCT post\u2010PCI and at 6\u2010month follow\u2010up. Maximum lipid core burden index in a 4\u2010mm segment (maxLCBI\n 4\u2009mm<\/jats:sub>\n ) was measured. The primary endpoint was percentage of covered stent struts (OCT) at 6\u2010month follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Pre\u2010PCI maxLCBI\n 4\u2009mm<\/jats:sub>\n was similar in the two groups (441 [239, 565] vs. 333 [242, 517],\n p<\/jats:italic>\n \u2009=\u20090.19). Imaging guidance resulted in a larger minimal stent area (7.3\u2009\u00b1\u20092.4\u2009mm\n 2<\/jats:sup>\n vs. 6.5\u2009\u00b1\u20091.7\u2009mm\n 2<\/jats:sup>\n ,\n p<\/jats:italic>\n \u2009=\u20090.04). At 6\u2010month follow\u2010up, stent strut coverage was higher in the imaging group (86.9% [77.7, 93.7] vs. 74.4% [53.8, 81.8],\n p<\/jats:italic>\n \u2009<\u20090.001). Segment\u2010level analyses showed that LRP without superficial attenuation and suboptimal stent expansion was associated with higher percentage of intima hyperplasia (23.4% [20.5, 25.9] vs. 13.9% [10.6, 16.0],\n p<\/jats:italic>\n \u2009<\u20090.001) compared to optimal stent expansion, whereas LRP with attenuation and suboptimal stent expansion was associated with higher rates of late\u2010acquired stent malapposition (81.8% vs. 30.0%,\n p<\/jats:italic>\n \u2009=\u20090.02) compared to optimal stent expansion.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Imaging\u2010guided PCI improved stent strut coverage. LRP phenotypes were associated with different healing patterns.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration Information<\/jats:title>\n \n Clinical Trial Registration Information: URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique identifier: NCT04460482.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ccd.70765","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:55:55Z","timestamp":1785286555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multimodality Intravascular Imaging Guidance (NIRS\u2013IVUS\u2013OCT) Compared to Angiography\u2010Guided Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction: The NIRVUS Trial"],"prefix":"10.1002","author":[{"given":"Manijeh","family":"Noori","sequence":"first","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Hougaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Columbia University Medical Center and Cardiovascular Research Foundation New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Tr\u00f8an","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-1713","authenticated-orcid":false,"given":"Kirstine N\u00f8rregaard","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Junker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Steen","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Veien","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ellert","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Flensted","family":"Lassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"10429","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0140-6736(23)02454-6","article-title":"Intravascular Imaging\u2010Guided Coronary Drug\u2010Eluting Stent Implantation: An Updated Network Meta\u2010Analysis","volume":"403","author":"Stone G. 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