{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:07:24Z","timestamp":1785139644870,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Murray law\u2010based quantitative flow ratio (\u03bcQFR) is an angiography\u2010derived physiological index that utilizes a single angiographic projection with artificial intelligence\u2010guided vessel segmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy and time efficacy of 2D\u2010\u03bcQFR against wire\u2010based fractional flow reserve (FFR\u2009\u2264\u20090.80), compare its performance with 3D\u2010\u03bcQFR and vessel\u2010FFR (vFFR), and assess feasibility in lesions excluded from vFFR analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This sub\u2010study of the prospective VERMONT trial analyzed 2D\u2010 and 3D\u2010\u03bcQFR retrospectively using prospectively acquired angiograms, with wire\u2010based FFR as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 209 patients with 225 intermediate lesions, 205 lesions were analyzed. 2D\u2010\u03bcQFR demonstrated excellent diagnostic accuracy for FFR\u2009\u2264\u20090.80 (AUC 0.95; 95% CI 0.93\u20130.98), with 93% sensitivity, 92% specificity, 88% positive predictive value (PPV), and 95% negative predictive value (NPV). Inter\u2010observer agreement was excellent (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.94,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and 2D\u2010\u03bcQFR analysis was 15.1\u2009min faster than wire\u2010based FFR (1.8\u2009\u00b1\u20090.7 vs. 16.9\u2009\u00b1\u20095.4\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Diagnostic performance was comparable to that of 3D\u2010\u03bcQFR, which achieved an AUC of 0.94 (95% CI 0.91\u20130.97), with 89% sensitivity, 90% specificity, 86% PPV, and 93% NPV. It was more specific than vFFR, which achieved an AUC of 0.92 (95% CI 0.89\u20130.96), with 90% sensitivity, 79% specificity, 74% PPV, and 93% NPV. Single\u2010projection analysis was feasible in 85% of lesions excluded from vFFR due to image quality limitations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Single\u2010projection 2D\u2010\u03bcQFR provides accurate, rapid, and reproducible physiological assessment comparable to 3D\u2010\u03bcQFR with superior specificity to vFFR. These findings support 2D\u2010\u03bcQFR as a practical, wire\u2010free alternative to invasive FFR in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70768","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:57:40Z","timestamp":1785139060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["VERMONT \u03bcQFR: Diagnostic Accuracy of Murray Law\u2010Based 2D\u2010\u03bcQFR Compared to 3D\u2010\u03bcQFR and vFFR"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-9094","authenticated-orcid":false,"given":"Daniel","family":"Akrawi","sequence":"first","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"Department of Cardiology Liverpool Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"},{"name":"Faculty of Medicine University of New South Wales Liverpool New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Kadappu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liverpool Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of New South Wales Liverpool New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer Yousef Naguib","family":"Badie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim","family":"Kachwalla","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phong T. D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Kurup","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upul","family":"Premawardhana","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyn","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health University of Sydney Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavie","family":"Soosapilla","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Basilakis","sequence":"additional","affiliation":[{"name":"School of Computer, Data &amp; Mathematical Sciences Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiden","family":"O'loughlin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Hennessy","sequence":"additional","affiliation":[{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"},{"name":"Faculty of Medicine and Health University of Sydney Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Femia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liverpool Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of New South Wales Liverpool New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"203","article-title":"Functional Coronary Angiography for the Assessment of the Epicardial Vessels and the Microcirculation","volume":"19","author":"Faria D.","year":"2023","journal-title":"EuroIntervention: Journal of EuroPCR in Collaboration With the Working Group on Interventional Cardiology of the European Society of Cardiology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s11886-022-01687-4","article-title":"Angiography\u2010Based Fractional Flow Reserve: State 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D.","year":"2025","journal-title":"Catheterization and Cardiovascular Interventions"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/ccd.29592","article-title":"Diagnostic Accuracy of Quantitative Flow Ratio for Assessment of Coronary Stenosis Significance From a Single Angiographic View: A Novel Method Based on Bifurcation Fractal Law","volume":"97","author":"Tu S.","year":"2021","journal-title":"Catheterization and Cardiovascular Interventions"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.5603\/CJ.a2022.0030","article-title":"Agreement Between Murray Law\u2010Based Quantitative Flow Ratio (\u03bcQFR) and Three\u2010Dimensional Quantitative Flow Ratio (3D\u2010QFR) in Non\u2010Selected Angiographic Stenosis: A Multicenter Study","volume":"29","author":"Cort\u00e9s C.","year":"2022","journal-title":"Cardiology 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J.","year":"2025","journal-title":"Cardiovascular Research"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/S0140-6736(24)02175-5","article-title":"Quantitative Flow Ratio Versus Fractional Flow Reserve for Coronary Revascularisation Guidance (FAVOR III Europe): A Multicentre, Randomised, Non\u2010Inferiority Trial","volume":"404","author":"Andersen B. 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