{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:49Z","timestamp":1785732409157,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The treatment of diffuse coronary artery disease is challenging, with high rates of repeat revascularization without satisfactory treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We designed a prospective, single\u2010center, single\u2010arm study to evaluate the feasibility and safety of a new strategy for the treatment of diffuse, small\u2010vessel coronary artery disease using a systematic combination of Scoring\u2010balloon Angioplasty and Sirolimus\u2010eluting balloon Angioplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included patients with diffuse (lesion length \u2265\u200920\u2009mm) and small vessel (diameter 1.5\u20132.75\u2009mm) coronary disease. Patients with STEMI, left main stenosis, and a life expectancy of less than 24 months were excluded. The procedure strategy was scoring\u2010balloon angioplasty (SBA), 1:1 diameter ratio with distal reference plus sirolimus\u2010eluting balloon angioplasty (SEB) using Mozec balloon (Meril, India).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From December 2022 until June 2025, 167 patients with 194 vessels were included. The mean age was 67\u2009\u00b1\u20099 years, 71% males, 92% with dyslipidemia, and 44% diabetics. The left anterior descending artery was the most frequently treated vessel (66%). The mean reference vessel diameter was 2.1\u2009\u00b1\u20090.74\u2009mm, MLD 0.71\u2009\u00b1\u20090.31\u2009mm, and %DS 67\u2009\u00b1\u200914%. The mean lesion length was 35\u2009\u00b1\u200915\u2009mm. For a median clinical follow\u2010up of 15 [8\u221229] months, the overall rate of MACE was 5.4%, 4.8% patients had TLR, and the total percentage of POCE was 10.2%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A novel strategy using a combination of scoring balloon angioplasty followed by sirolimus\u2010eluting balloon inflation for the treatment of diffuse coronary artery disease yields promising angiographic and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70784","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:42:49Z","timestamp":1785732169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes After Scoring\u2010Balloon and Sirolimus\u2010Eluting Balloon Strategy in Diffuse Small\u2010Vessel Coronary Artery Disease (SCA\u2010DEB Study): A Single\u2010Center Prospective Study"],"prefix":"10.1002","author":[{"given":"Dobrin","family":"Vassilev","sequence":"first","affiliation":[{"name":"Medica Cor Hospital Ruse Bulgaria"},{"name":"Ruse University \u201cAngel Kanchev\u201d Ruse Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-0181","authenticated-orcid":false,"given":"Niya","family":"Mileva","sequence":"additional","affiliation":[{"name":"Medica Cor Hospital Ruse Bulgaria"},{"name":"Medical University of Pleven Pleven Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayot","family":"Panayotov","sequence":"additional","affiliation":[{"name":"Medica Cor Hospital Ruse Bulgaria"},{"name":"Ruse University \u201cAngel Kanchev\u201d Ruse Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Shurupov","sequence":"additional","affiliation":[{"name":"Medica Cor Hospital Ruse Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilter","family":"Pazardzhakli","sequence":"additional","affiliation":[{"name":"Medica Cor Hospital Ruse Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavril","family":"Stoev","sequence":"additional","affiliation":[{"name":"Medica Cor Hospital Ruse Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawomir","family":"Golebiewski","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Internal Diseases Military National Research Institute Legionowo Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Rigatelli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Padova South Hospitals Monselice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Gil","sequence":"additional","affiliation":[{"name":"National Medical Institute of Internal Affairs and Administration Ministry Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"issue":"11","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jcin.2011.07.016","article-title":"Impact of Lesion Length and Vessel Size on Clinical Outcomes After Percutaneous Coronary Intervention With Everolimus\u2010 Versus Paclitaxel\u2010Eluting Stents Pooled Analysis From the SPIRIT (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System) and COMPARE (Second\u2010Generation Everolimus\u2010Eluting and Paclitaxel\u2010Eluting Stents in Real\u2010Life Practice) Randomized Trials","volume":"4","author":"Claessen B. E.","year":"2011","journal-title":"JACC Cardiovascular Interventions"},{"issue":"4","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.33963\/v.phj.100213","article-title":"Side Branch Predilatation During Percutaneous Coronary Bifurcation Intervention: Long\u2010Term Mortality Analysis","volume":"82","author":"Vassilev D.","year":"2024","journal-title":"Polish Heart Journal"},{"issue":"6","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.5603\/CJ.a2022.0078","article-title":"A Novel Technique of Proximal Optimization With Kissing Balloon Inflation in Bifurcation Lesions","volume":"29","author":"Vassilev D.","year":"2022","journal-title":"Cardiology Journal"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ahj.2019.03.011","article-title":"Incidence and Predictors of Target Lesion Failure in Patients Undergoing Contemporary DES Implantation\u2010Individual Patient Data Pooled Analysis From 6 Randomized Controlled Trials","volume":"213","author":"Konigstein M.","year":"2019","journal-title":"American Heart Journal"},{"issue":"9","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3390\/medicina60091439","article-title":"Current Challenges in Coronary Bifurcation Interventions","volume":"60","author":"Panayotov P.","year":"2024","journal-title":"Medicina"},{"issue":"10150","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(18)31719-7","article-title":"Drug\u2010Coated Balloons for Small Coronary Artery Disease (BASKET\u2010SMALL 2): An Open\u2010Label Randomised Non\u2010Inferiority Trial","volume":"392","author":"Jeger R. V.","year":"2018","journal-title":"Lancet"},{"issue":"17","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/eurheartj\/ehaf002","article-title":"Individual Patient Data Meta\u2010Analysis of Paclitaxel\u2010Coated Balloons vs. Drug\u2010Eluting Stents for Small\u2010Vessel Coronary Artery Disease: The ANDROMEDA Study","volume":"46","author":"Fezzi S.","year":"2025","journal-title":"European Heart Journal"},{"issue":"3","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ccd.31154","article-title":"Paclitaxel\u2010Coated Versus Sirolimus\u2010Coated Balloon Angioplasty for Coronary Artery Disease: A Systematic Review and Meta\u2010Analysis","volume":"104","author":"Shin D.","year":"2024","journal-title":"Catheterization and Cardiovascular Interventions: Official Journal of the Society for Cardiac Angiography & Interventions"},{"issue":"2","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.14740\/cr2026","article-title":"Safety and Performance of the MOZEC Sirolimus\u2010Eluting Coronary Balloon in the Treatment of Stenotic Coronary Artery Lesions: A Real\u2010World, Multicenter, Post\u2010Marketing Surveillance Study","volume":"16","author":"Premchand Jain R. K.","year":"2025","journal-title":"Cardiology Research"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf029"},{"issue":"2","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2459\/JCM.0000000000001070","article-title":"Clinical Performance of a Novel Sirolimus\u2010Coated Balloon in Coronary Artery Disease: EASTBOURNE Registry","volume":"22","author":"Cortese B.","year":"2021","journal-title":"Journal of Cardiovascular Medicine"},{"issue":"24","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.jacc.2012.09.020","article-title":"A Randomized Multicenter Study Comparing a Paclitaxel Drug\u2010Eluting Balloon With a Paclitaxel\u2010Eluting Stent in Small Coronary Vessels","volume":"60","author":"Latib A.","year":"2012","journal-title":"Journal of the American College of Cardiology"},{"issue":"5","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0002-9149(91)90780-O","article-title":"Use of a Morphologic Classification to Predict Clinical Outcome After Dissection From Coronary Angioplasty","volume":"68","author":"Huber M. S.","year":"1991","journal-title":"American Journal of Cardiology"},{"issue":"24","key":"e_1_2_11_15_1","first-page":"2840","article-title":"Drug\u2010Coated Balloon Versus Drug\u2010Eluting Stent for Small Coronary Vessel Disease","volume":"13","author":"Cortese B.","year":"2020","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"23","key":"e_1_2_11_16_1","first-page":"2884","article-title":"A Prospective Randomized Trial Comparing Sirolimus\u2010Coated Balloon With Paclitaxel\u2010Coated Balloon in De Novo Small Vessels","volume":"16","author":"Ninomiya K.","year":"2023","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"10457","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S0140-6736(24)01594-0","article-title":"Drug\u2010Coated Balloon Angioplasty With Rescue Stenting Versus Intended Stenting for the Treatment of Patients With De Novo Coronary Artery Lesions (REC\u2010CAGEFREE I): An Open\u2010Label, Randomised, Non\u2010Inferiority Trial","volume":"404","author":"Gao C.","year":"2024","journal-title":"Lancet"},{"issue":"24","key":"e_1_2_11_18_1","first-page":"2850","article-title":"Leave Nothing Behind","volume":"13","author":"Kereiakes D. J.","year":"2020","journal-title":"JACC: Cardiovascular Interventions"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:43:04Z","timestamp":1785732184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":17,"alternative-id":["10.1002\/ccd.70784"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70784","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]},"assertion":[{"value":"2026-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ccd.70784"}}