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The demonstration of clopidogrel resistance and the relation of high platelet reactivity to ADP to recurrent ischemic event occurrences in patients with coronary artery disease treated with stents significantly influenced the development of potent P2Y\n                    <jats:sub>12<\/jats:sub>\n                    receptor inhibitors. A \u201cone size fits all\u201d strategy of clopidogrel therapy is associated with a greater risk for recurrent thrombotic events compared to uniform use of potent P2Y\n                    <jats:sub>12<\/jats:sub>\n                    receptor inhibitors which causes more bleeding. The concept of a therapeutic window for P2Y\n                    <jats:sub>12<\/jats:sub>\n                    inhibitor therapy that strikes a balance between the attenuation of thrombotic risk and bleeding has been used to personalize antiplatelet therapy. Despite the absence of a strong recommendation in the current guidelines for platelet function testing or genetic testing, the treating interventionalist must rely on the available evidence base, as summarized in this Review, to help decide whether to employ a one\u2010size\u2010fits\u2010all strategy of antiplatelet therapy or one that is personalized by objective testing.\n                  <\/jats:p>","DOI":"10.1002\/ccd.70794","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:39:39Z","timestamp":1785929979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["State of the Art: Personalized Antiplatelet Therapy by Genotype and Platelet Function Testing"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-568X","authenticated-orcid":false,"given":"Paul A.","family":"Gurbel","sequence":"first","affiliation":[{"name":"Sinai Center for Thrombosis Research and Drug Development Sinai Hospital of Baltimore and Lifebridge Health System Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0403-3726","authenticated-orcid":false,"given":"Young\u2010Hoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Gwangmyeong and Department of Internal Medicine, CAU Thrombosis and Biomarker Center Chung\u2010Ang University Gwangmyeong Hospital, Chung\u2010Ang University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-4589","authenticated-orcid":false,"given":"Eliano","family":"Navarese","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Link Campus University Rome Italy"},{"name":"Collegium Medicum in Bydgoszcz Nicolaus Copernicus University Bydgoszcz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-754X","authenticated-orcid":false,"given":"Jacek","family":"Kubica","sequence":"additional","affiliation":[{"name":"Collegium Medicum in Bydgoszcz Nicolaus Copernicus University Bydgoszcz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-2621","authenticated-orcid":false,"given":"Bogumil","family":"Ramotowski","sequence":"additional","affiliation":[{"name":"Cardiology Department Centre of Postgraduate Medical Education, Grochowski Hospital Warsaw Grenadierow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-8596","authenticated-orcid":false,"given":"Udaya S.","family":"Tantry","sequence":"additional","affiliation":[{"name":"Sinai Center for Thrombosis Research and Drug Development Sinai Hospital of Baltimore and Lifebridge Health System Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.031195"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.853085"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072771.11429.83"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.101"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.08.027"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809171"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.851949"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61274-3"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.01.024"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2217\/14796678.2.3.343"},{"issue":"9","key":"e_1_2_14_12_1","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1161\/CIRCRESAHA.115.307016","article-title":"Platelet\u2010Mediated Thrombosis: From Bench to Bedside","volume":"118","author":"Gurbel P. 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