{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:28:14Z","timestamp":1786598894989,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mitral valve transcatheter\u2010edge\u2010to\u2010edge repair (M\u2010TEER) is routinely performed in patients with severe mitral regurgitation (MR) at high operative risk, frequently including elderly patients. Patients \u2265\u200985 years, however, are frequently excluded in clinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated differences of procedural characteristics and outcomes following M\u2010TEER in patients &lt; versus \u2265\u200985 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included consecutive patients with severe MR who underwent M\u2010TEER with the PASCAL device between 2019 and 2024 at our center. Baseline and procedural characteristics, short\u2010 and mid\u2010term outcomes were compared, stratifying the cohort into patients &lt; versus \u2265\u200985 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three hundred seventy\u2010five patients with moderate to severe or severe MR were eligible; 71 aged \u2265\u200985 (87.0\u2009\u00b1\u20091.7 years, 57.7% male) and 304 aged &lt;\u200985 (75.5\u2009\u00b1\u200910.0 years, 58.6% male) years. Patients aged \u2265\u200985 years more frequently had severe MR (90.1% vs. 73.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and higher STS\u2010Score (6.4 [3.8; 9.1] vs. 3.5 [2.2; 6.5],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) at baseline. No leaflet injury, single leaflet detachment or any other device\u2010related complication was observed, irrespective of age. Residual MR at 90 days was comparable among age groups (Trace: 34.8% vs. 23.8%; mild: 41.3% vs. 57.3%; moderate: 23.9% vs. 18.5%; moderate\u2010severe: 0% vs. 0.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.56). Within 30 days, no death occurred in patients aged \u2265\u200985 years (one death in the &lt;\u200985 years group). Median mid\u2010term follow\u2010up was 430 [164; 692] days. Overall mortality was not different for patients \u2265 versus &lt;\u200985 years (5.6% vs. 7.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.76).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>M\u2010TEER is safe in patients \u2265\u200985 years, with procedural outcomes and mid\u2010term prognosis similar to younger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70807","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:54:32Z","timestamp":1786596872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interventional Mitral Valve Edge\u2010to\u2010Edge Repair in Patients Above 85 Years of Age"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8746-3617","authenticated-orcid":false,"given":"Florian","family":"J\u00fcrgens","sequence":"first","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen University Hospital Essen, University of Duisburg\u2010Essen Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schindhelm","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen University Hospital Essen, University of Duisburg\u2010Essen Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Abusharekh","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen University Hospital Essen, University of Duisburg\u2010Essen Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8370-6882","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Kampf","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen University Hospital Essen, University of Duisburg\u2010Essen Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Totzeck","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen University Hospital Essen, University of Duisburg\u2010Essen Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Al\u2010Rashid","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen University Hospital Essen, University of Duisburg\u2010Essen Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"L\u00fcdike","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen University Hospital Essen, University of Duisburg\u2010Essen Duisburg Germany"},{"name":"Department of Cardiology and Intensive Care Medicine Niels\u2010Stensen\u2010Kliniken, Marienhospital Osnabr\u00fcck Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienush","family":"Rassaf","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen University Hospital Essen, University of Duisburg\u2010Essen Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A.","family":"Mahabadi","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular 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