{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:49:03Z","timestamp":1791319743992,"version":"4.3.1"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aorto\u2010ostial coronary lesions represent a high\u2010risk subset of coronary disease because of fibrocalcific disease, elastic recoil, and difficulty achieving precise stent positioning. Percutaneous coronary intervention (PCI) of these lesions may therefore be associated with less favourable outcomes than of proximal non\u2010ostial lesions. Furthermore, ostial left main coronary artery (LMCA) and right coronary artery (RCA) lesions differ in anatomy and myocardium at risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare procedural practice and outcomes of aorto\u2010ostial versus proximal non\u2010ostial PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed patients from the multicentre Melbourne Interventional Group Registry who underwent PCI between 2005 and 2020. Patients treated for ostial LMCA or ostial RCA lesions (aorto\u2010ostial lesion [AOL] group) were compared with those undergoing PCI for proximal non\u2010ostial LMCA or RCA lesions (non\u2010AOL group). The primary outcome was long\u2010term mortality. Secondary outcomes were in\u2010hospital and 30\u2010day major adverse cardiovascular events (MACE), with multivariable logistic regression used to identify independent predictors of 30\u2010day MACE. Vessel\u2010specific analysis compared ostial and non\u2010ostial LMCA and RCA PCI separately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 4683 PCI procedures, 538 (11.5%) underwent PCI for AOL and 4145 (88.5%) for proximal non\u2010ostial LMCA or RCA lesions. Patients in the AOL group were older (70.1 vs. 65.0 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), more often female (37.7% vs. 25.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and had a greater burden of comorbidity and lesion complexity. Rotational atherectomy (4.5% vs. 1.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and intravascular ultrasound (5.9% vs. 1.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were used more frequently in the AOL group, although overall use was low. AOL location was not independently associated with 30\u2010day MACE (adjusted OR 0.93, 95% CI 0.60\u22121.45;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.76). Long\u2010term survival was lower in the pooled AOL cohort (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); vessel\u2010specific analysis showed no difference for LMCA PCI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.69), whereas survival was lower after ostial RCA PCI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients undergoing AOL PCI had a higher\u2010risk clinical profile but similar adjusted early outcomes. In vessel\u2010specific analyses, the pooled long\u2010term survival difference appeared predominantly attributable to the RCA cohort, with no difference between ostial and non\u2010ostial LMCA PCI. This may reflect differences in baseline patient risk rather than excess periprocedural risk alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70817","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:18:56Z","timestamp":1787077136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aorto\u2010Ostial Lesion Percutaneous Coronary Intervention: Clinical Characteristics, Predictors and Clinical Outcomes"],"prefix":"10.1002","author":[{"given":"Simon M.","family":"Thackray","sequence":"first","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-3185","authenticated-orcid":false,"given":"Riley J.","family":"Batchelor","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital Melbourne Australia"},{"name":"Monash University Melbourne Australia"},{"name":"Department of Cardiology, Alfred Health Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diem","family":"Dinh","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Brennan","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7260-5924","authenticated-orcid":false,"given":"Millie","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Eastern Health Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Austin Health Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Reid","sequence":"additional","affiliation":[{"name":"Curtin University Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dion","family":"Stub","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Australia"},{"name":"Department of Cardiology, Alfred Health Melbourne Australia"},{"name":"Ambulance Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Oqueli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ballarat Health Services Ballarat Australia"},{"name":"Deakin University Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin","family":"Hiew","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barwon Health Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eccleston","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital Melbourne Australia"},{"name":"Department of Cardiology, Western Health Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop N.","family":"Koshy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital Melbourne Australia"},{"name":"Department of Cardiology, Austin Health Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ajani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinjini","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital Melbourne Australia"},{"name":"Monash University Melbourne Australia"},{"name":"Department of Cardiology, Alfred Health Melbourne 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Incidence of Inaccurate Stent Placement in the Treatment of Coronary Aorto\u2010Ostial Disease","volume":"23","author":"Dishmon D. 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