{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:18:09Z","timestamp":1788247089708,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Percutaneous patent foramen ovale (PFO) closure is established for selected patients with PFO\u2010associated cryptogenic stroke and other dedicated indications; however, long\u2010term outcome data remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Evaluate procedural, echocardiographic, and long\u2010term clinical outcomes after percutaneous PFO closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients undergoing PFO closure at Heart Center Lucerne between February 2017 and December 2024 were analyzed. The primary endpoint was a combined endpoint of recurrent cerebrovascular events and death. Follow\u2010up included 6\u2010month echocardiography and clinical follow\u2010up up to 8 years using electronic health records and structured telephone interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 331 patients (mean age 51\u2009\u00b1\u200912 years, 39% women, 80% prior cryptogenic stroke) were analyzed. Atrial septal aneurysm was present in 31%, grade 3 shunt in 72%, and the median RoPE score was 7 (IQR 6\u20137). Technical success was 99%. Devices used were Amplatzer (52%), Figulla Flex (42%), NobleStitch (6%), and Gore (1%). Double\u2010disc devices achieved higher effective closure (residual shunt \u2264 grade 1) than suture\u2010based closure (97% vs. 68%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); a double\u2010disc closure for relevant residual shunt was required after 7\/21 suture\u2010based closures. During a median follow\u2010up of 3.7 years (IQR 2.1\u20135.7) 12 patients had a primary outcome (three ischemic strokes, two hemorrhagic strokes, five transient\u2010ischemic\u2010attacks, and two deaths). The primary outcome rate was 0.93\/100 patient\u2010years and stroke recurrence rate was 0.39 per 100 patient\u2010years. Residual shunt grade \u2265\u20092 showed a trend toward increased cerebrovascular risk (HR 4.3, 95% CI 0.9\u201320.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.068). Atrial fibrillation was documented in 5.4% of patients during long\u2010term follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Percutaneous PFO closure showed high technical success and low long\u2010term ischemic stroke recurrence. Double\u2010disc devices provided higher effective closure than suture\u2010based closure, and residual shunt may indicate increased cerebrovascular risk. A considerable proportion of patients developed atrial fibrillation following PFO closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70818","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:09:11Z","timestamp":1788246551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Stroke Recurrence and Safety After Percutaneous Patent Foramen Ovale Closure: Results From the Lucerne Registry"],"prefix":"10.1002","author":[{"given":"David F.","family":"M\u00f6ller","sequence":"first","affiliation":[{"name":"Heart Center Lucerne Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-5676","authenticated-orcid":false,"given":"Federico","family":"Moccetti","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne Luzerner Kantonsspital Lucerne 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