{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:26:17Z","timestamp":1787034377013,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015101","name":"Ramsay Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Evolut and the Navitor transcatheter heart valves (THVs) represent the most widely used self\u2010expanding implanted valves. Despite a similar implant concept, they markedly differ in design and hemodynamic performance. In both THVs, conduction disturbances following transcatheter aortic valve replacement (TAVR) are reported higher than in balloon\u2010expandable devices. Nevertheless, to date, no direct comparative studies have analyzed their real difference rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Aim of the present study was to directly compare the self\u2010expanding Evolut PRO+ and Navitor THVs, with specific focus on the incidence of new permanent pacemaker implantation (PPI) and post\u2010procedural hemodynamic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The CONNAVIPRO registry is an international, multicenter, retrospective study including 880 consecutive patients with severe aortic stenosis treated with Evolut PRO+ (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009451) or Navitor (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009429) between May 2022 and December 2024. The primary endpoint was new PPI within 30 days among pacemaker\u2010na\u00efve patients. Secondary endpoints included technical and device success, transprosthetic gradients, and paravalvular leak (PVL). Inverse probability weighting (IPW) was applied to adjust for baseline differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Procedural success was high with both valves (97.6%), and early safety outcomes were comparable. At 30 days, the Navitor group showed a higher PPI rate than Evolut (23.2% vs. 17.6%), reaching statistical significance after IPW adjustment (OR 1.53, 95% CI 1.08\u20132.17;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). Mean transprosthetic gradients were slightly higher with Navitor (8 vs. 7\u2009mmHg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), whereas moderate or greater PVL was less frequent (2.8% vs. 7.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Variables independently associated with PPI were hypertension, and pre\u2010existing right bundle branch block.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both Evolut PRO+ and Navitor THVs provided excellent safety and hemodynamic outcomes. Navitor may be associated with a higher 30\u2010day PPI rate, a lower incidence of moderate or greater PVL, and clinically non\u2010significant higher gradients. These associations should be interpreted as hypothesis\u2010generating and warrant confirmation in prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70827","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:50:38Z","timestamp":1787032238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conduction Disturbances and Permanent Pacemaker Implantation After TAVR With Self\u2010Expanding Devices: The CONNAVIPRO Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-505X","authenticated-orcid":false,"given":"Enrico","family":"Poletti","sequence":"first","affiliation":[{"name":"Institut Cardio Vasculaire de Caen (ICVC) \u2013 H\u00f4pital Priv\u00e9 Caen Saint Martin France"},{"name":"Structural Heart Department, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5538-5222","authenticated-orcid":false,"given":"Omar Alessandro","family":"Oliva","sequence":"additional","affiliation":[{"name":"Groupe Cardio Vasculaire Interventionnel (GCVI) Clinique Pasteur Toulouse France"},{"name":"Interventional Cardiology Unit, IRCCS Multimedica, Sesto San Giovanni Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9189-4090","authenticated-orcid":false,"given":"Ahmad","family":"Hassan","sequence":"additional","affiliation":[{"name":"Institut Cardio Vasculaire de Caen (ICVC) \u2013 H\u00f4pital Priv\u00e9 Caen Saint Martin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Esposito","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, De Gasperis Cardio Center, Niguarda Hospital, Piazza Ospedale Maggiore 3 Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-440X","authenticated-orcid":false,"given":"Mauro","family":"Massussi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties ASST Spedali Civili di Brescia, Radiological Sciences, and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ardizzone","sequence":"additional","affiliation":[{"name":"Structural and Valvular Interventional Cardiology Unit, IRCCS Centro Cardiologico Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2459-5051","authenticated-orcid":false,"given":"Baydaroglu","family":"Nurcan","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, De Gasperis Cardio Center, Niguarda Hospital, Piazza Ospedale Maggiore 3 Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7184-4872","authenticated-orcid":false,"given":"Antonella","family":"Millin","sequence":"additional","affiliation":[{"name":"Groupe Cardio Vasculaire Interventionnel (GCVI) Clinique Pasteur Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Zuccarelli","sequence":"additional","affiliation":[{"name":"Institut Cardio Vasculaire de Caen (ICVC) \u2013 H\u00f4pital Priv\u00e9 Caen Saint Martin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5108-0579","authenticated-orcid":false,"given":"Andrea Raffaele","family":"Munaf\u00f2","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, De Gasperis Cardio Center, Niguarda Hospital, Piazza Ospedale Maggiore 3 Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-7696","authenticated-orcid":false,"given":"Jacopo","family":"Oreglia","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, De Gasperis Cardio Center, Niguarda Hospital, Piazza Ospedale Maggiore 3 Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3554-6938","authenticated-orcid":false,"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"Structural and Valvular Interventional Cardiology Unit, IRCCS Centro Cardiologico Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-1815","authenticated-orcid":false,"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties ASST Spedali Civili di Brescia, Radiological Sciences, and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Tchetch\u00e9","sequence":"additional","affiliation":[{"name":"Groupe Cardio Vasculaire Interventionnel (GCVI) Clinique Pasteur Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zuffi","sequence":"additional","affiliation":[{"name":"Institut Cardio Vasculaire de Caen (ICVC) \u2013 H\u00f4pital Priv\u00e9 Caen Saint Martin France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"18","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter Aortic\u2010Valve Replacement With a Balloon\u2010Expandable Valve in Low\u2010Risk Patients","volume":"380","author":"Mack M. 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R.","year":"2025","journal-title":"Lancet"},{"issue":"19","key":"e_1_2_10_10_1","first-page":"e259","article-title":"Technical Considerations for Transcatheter Aortic Valve Replacement With the Navitor Transcatheter Heart Valve","volume":"14","author":"Wong I.","year":"2021","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"21","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa2312573","article-title":"Self\u2010Expanding or Balloon\u2010Expandable TAVR in Patients With a Small Aortic Annulus","volume":"390","author":"Herrmann H. 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C.","year":"2022","journal-title":"Clinical Kidney Journal"},{"issue":"2","key":"e_1_2_10_21_1","first-page":"115","article-title":"Incidence, Predictors, and Implications of Permanent Pacemaker Requirement After Transcatheter Aortic Valve Replacement","volume":"14","author":"Sammour Y.","year":"2021","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"2","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/ccd.30517","article-title":"Impact of Implantation Technique on Conduction Disturbances for TAVR With the Self\u2010Expanding Portico\/Navitor Valve","volume":"101","author":"Wang X.","year":"2023","journal-title":"Catheterization and Cardiovascular Interventions"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.amjcard.2023.05.025","article-title":"Conduction Disturbance After Transcatheter Aortic Valve Implantation With Self\u2010 or Balloon\u2010Expandable Valve According to the Implantation Depth","volume":"203","author":"Miyashita H.","year":"2023","journal-title":"American Journal of Cardiology"},{"issue":"12","key":"e_1_2_10_24_1","first-page":"1557","article-title":"Transcatheter Aortic Valve Replacement With Intra\u2010Annular Self\u2010Expanding or Balloon\u2010Expandable Valves","volume":"18","author":"Cannata S.","year":"2025","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"16","key":"e_1_2_10_25_1","first-page":"2004","article-title":"30\u2010Day and 1\u2010Year Outcomes From the Optimize PRO TAVR Evolut FX Addendum Study","volume":"18","author":"Gada H.","year":"2025","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"2","key":"e_1_2_10_26_1","first-page":"170","article-title":"Three Generations of Self\u2010Expanding Transcatheter Aortic Valves","volume":"13","author":"Forrest J. 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