{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:07:04Z","timestamp":1788955624508,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Due to nitinol stent properties, self\u2010expanding transcatheter heart valves (THVs) have the potential to adapt their frames to native annular dimension excursions during the cardiac cycle and therefore to maintain the physiological relevance of this behaviour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the in\u2010vivo variations of THV frame dimensions during the cardiac cycle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing transcatheter aortic valve replacement (TAVR) with self\u2010expanding THV platforms enrolled in the RE\u2010ACCESS 2 study were considered. Patients with post\u2010TAVR four\u2010dimensional computed tomography (4\u2010D CT) assessment not eligible for stent frame analysis were excluded from the analysis. The THV frame dimensions were assessed at three levels: inflow edge, native virtual basal ring (VBR) and bioprosthetic leaflets plane (BLP). Measurements were performed in systolic (30\u00b0 of the cardiac cycle) and diastolic (70\u00b0 of the cardiac cycle) phase acquisitions for each patient. Stent expansion was reported as the difference among systolic and diastolic measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among a total of 127 patients, 83 patients were considered eligible for the present analysis. Forty\u2010nine and 34 patients received Evolut and Acurate Neo2 THV, respectively. Stent frame expansion across the cardiac cycle was encountered at VBR (median perimeter variability 0.30\u2009mm) and BLP (median perimeter variability 0.25\u2009mm) levels, but not at the inflow level (median perimeter variability \u22120.05\u2009mm). Acurate Neo2 had greater variability compared to Evolut THVs (VBR median perimeter variability 0.50\u2009mm vs. 0.10\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02; BLP median perimeter variability 0.60\u2009mm vs. 0.20\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Self\u2010expanding THVs exhibited dynamic behavior throughout the cardiac cycle, with stent expansion during systole at both VBR and BLP levels. Stent design influenced this dynamicity, as Acurate Neo2 had greater stent variability compared to Evolut THV. Whether these features affect long\u2010term THV durability remains to be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70855","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:17:05Z","timestamp":1788952625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In\u2010Vivo Frame Dynamicity of Self\u2010Expanding Transcatheter Aortic Valves"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5174-5477","authenticated-orcid":false,"given":"Mariachiara","family":"Cal\u00ec","sequence":"first","affiliation":[{"name":"Division of Cardiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4985-1327","authenticated-orcid":false,"given":"Sofia","family":"Sammartino","sequence":"additional","affiliation":[{"name":"Division of Cardiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7780-4574","authenticated-orcid":false,"given":"Luigi La","family":"Rosa","sequence":"additional","affiliation":[{"name":"Division of Cardiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3277-4380","authenticated-orcid":false,"given":"Salvatore Giovanni","family":"Impellizzeri","sequence":"additional","affiliation":[{"name":"Division of Cardiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5159-4512","authenticated-orcid":false,"given":"Marco","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Division of Cardiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7647-0876","authenticated-orcid":false,"given":"Alessia","family":"Loibiso","sequence":"additional","affiliation":[{"name":"Division of Cardiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Frittitta","sequence":"additional","affiliation":[{"name":"Division of Cardiology Umberto I Hospital, ASP Siracusa Syracuse Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Dipietro","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1240-7556","authenticated-orcid":false,"given":"Alessandro","family":"Comis","sequence":"additional","affiliation":[{"name":"Centro Cuore Morgagni Pedara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Garretto","sequence":"additional","affiliation":[{"name":"Division of Radiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Inserra","sequence":"additional","affiliation":[{"name":"Division of Radiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-0477","authenticated-orcid":false,"given":"Maria Teresa","family":"Cannizzaro","sequence":"additional","affiliation":[{"name":"Division of Radiology A.O.U. Policlinico \u201cG. Rodolico\u2010San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4903-5437","authenticated-orcid":false,"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Enna \u201cKore\u201d Enna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-8988","authenticated-orcid":false,"given":"Giuliano","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Cardiology A.O.U. Policlinico \u201cG. 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