{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:45:05Z","timestamp":1792071905013,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patent foramen ovale (PFO) has been identified as a conduit for paradoxical embolism causing stroke or transient ischemic attack (TIA). Long\u2010term data of PFO closure beyond 10 years are rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to report the very long\u2010term outcomes of PFO closure and compare the efficacy of different post?procedural antithrombotic treatment (AT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Very long\u2010term outcomes of a previously reported cohort of patients undergoing PFO closure between May 2004 and January 2013 were reviewed. Outcomes, including recurrent stroke or TIA, bleeding, venous thromboembolism (VTE), newly diagnosed atrial fibrillation (AF), and all\u2010cause death, were adjudicated. The cohort was further stratified into short\u2010 and long\u2010term post\u2010procedural AT groups. Propensity\u2010score matching was performed to adjust for differences in baseline characteristics across subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three hundred and one patients were included in the analysis. Median follow\u2010up duration was 15.0 [95% confidence interval 14.7\u221215.3] years. Stroke and TIA occurred in 3.4% (0.27 per 100 patient\u2010year) and 6.2% (0.46 per 100 patient\u2010year), respectively. Bleeding and VTE were noted in 3.8% and 6.5%. 9.6% of patients (0.71 per 100 patient\u2010year) developed AF. Thirty patients (0.70 per 100 patient\u2010year) died. Patients receiving long\u2010term AT (a single antiplatelet in &gt;\u200985% of the population) experienced more bleeding and major bleeding events (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03 and 0.02, respectively), and had a tendency toward more frequent bleeding after propensity score matching (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09). Other outcome events were similar between subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Benefits from PFO closure persist over the long term. A limited post\u2010closure AT regimen is equally effective in preventing recurrent embolic events and is associated with potentially less bleeding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70863","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:07:46Z","timestamp":1789020466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patent Foramen Ovale Closure Following Cryptogenic Embolism: Very Long\u2010Term Follow\u2010Up of a Historical Cohort"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9326-2648","authenticated-orcid":false,"given":"Siu\u2010Fung","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sussex Cardiac Centre University Hospitals Sussex Brighton UK"},{"name":"Department of Medicine and Geriatrics, Division of Cardiology United Christian Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-0129","authenticated-orcid":false,"given":"Mohamed","family":"Aboulesaad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sussex Cardiac Centre University Hospitals Sussex Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6333-058X","authenticated-orcid":false,"given":"Thomas","family":"Oswald","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sussex Cardiac Centre University Hospitals Sussex Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8703-851X","authenticated-orcid":false,"given":"Timothy","family":"Bagnall","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sussex Cardiac Centre University Hospitals Sussex Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Broyd","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sussex Cardiac Centre University Hospitals Sussex Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Cockburn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sussex Cardiac Centre University Hospitals Sussex Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-9421","authenticated-orcid":false,"given":"Joao","family":"Ferreira\u2010Martins","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sussex Cardiac Centre University Hospitals Sussex Brighton 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