{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:06:16Z","timestamp":1788933976340,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intravascular lithotripsy (IVL) has emerged as an effective technique for modifying heavily calcified coronary plaques, facilitating optimal stent expansion while minimizing procedural complications. However, data on periprocedural myocardial injury (PMI) and infarction (PPMI) following IVL remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the incidence of PMI and PPMI after IVL in an unselected real\u2010world population undergoing percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive patients treated with IVL between May 2020 and December 2022 at a single tertiary center were included. Pre\u2010 and post\u2010procedural cardiac biomarkers (high\u2010sensitivity troponin T, CK, CK\u2010MB) and electrocardiograms were systematically analyzed. PMI and PPMI were defined according to the Fourth Universal Definition of Myocardial Infarction. A matched control cohort (2147 non\u2010IVL PCI patients) was used to compare biomarker dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 90 patients (mean age 73\u2009\u00b1\u20099 years; 77% male), diameter stenosis decreased from 55.2%\u2009\u00b1\u200915.5% before IVL to 40.3%\u2009\u00b1\u200915.7% immediately after IVL, with a final residual stenosis of 5.5%\u2009\u00b1\u200918.5% after PCI and increased median minimal lumen diameter from 1.22 [0.72\u20131.72] mm to 3.04 [2.64\u20133.57] mm. High\u2010sensitivity troponin and CK\u2010MB levels rose modestly following IVL\u2010assisted PCI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), indicating mild myocardial injury. PMI was present in 49 patients (54%). Two patients met the criteria for PPMI, and no major procedural complication occurred. In an exploratory matched\u2010control analysis, IVL was associated with a moderate but statistically significant increase in biomarkers compared with matched controls (Cohen's d\u2009=\u20090.40).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single\u2010center observational study, IVL was associated with limited myocardial injury, while clinically overt PPMI remained uncommon. These findings support the favorable safety profile of IVL as a plaque\u2010modification strategy for complex calcified coronary lesions.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>ClinicalTrials.gov Identifier:<\/jats:bold>\n                      NCT04185285.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70868","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:06:59Z","timestamp":1788930419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of Periprocedural Myocardial Injury and Infarction After Intravascular Lithotripsy for Calcified Coronary Artery Stenosis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4921-4696","authenticated-orcid":false,"given":"Gwaenaelle","family":"Aellen","sequence":"first","affiliation":[{"name":"Cardiology, University and Hospital Fribourg Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-3496","authenticated-orcid":false,"given":"Dorian","family":"Garin","sequence":"additional","affiliation":[{"name":"Cardiology, University and Hospital Fribourg Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-8684","authenticated-orcid":false,"given":"Yannick","family":"Faucherre","sequence":"additional","affiliation":[{"name":"Cardiology, University and Hospital Fribourg Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serban","family":"Puricel","sequence":"additional","affiliation":[{"name":"Cardiology, University and Hospital Fribourg Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4673-3599","authenticated-orcid":false,"given":"Mario","family":"Togni","sequence":"additional","affiliation":[{"name":"Cardiology, University and Hospital Fribourg Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1221-2978","authenticated-orcid":false,"given":"St\u00e9phane","family":"Cook","sequence":"additional","affiliation":[{"name":"Cardiology, University and Hospital Fribourg Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"22","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1016\/j.jacc.2020.09.603","article-title":"Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Artery Disease","volume":"76","author":"Hill J. M.","year":"2020","journal-title":"Journal of the American College of Cardiology"},{"issue":"10","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008434","article-title":"Safety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses: The Disrupt CAD II Study","volume":"12","author":"Ali Z. A.","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"issue":"6","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/CIRCULATIONAHA.118.036531","article-title":"Feasibility of Shockwave Coronary Intravascular Lithotripsy for the Treatment of Calcified Coronary Stenoses: First Description","volume":"139","author":"Brinton T. J.","year":"2019","journal-title":"Circulation"},{"issue":"6","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1253\/circj.CJ-20-1174","article-title":"Intravascular Lithotripsy for Vessel Preparation in Severely Calcified Coronary Arteries Prior to Stent Placement\u2015Primary Outcomes From the Japanese Disrupt CAD IV Study","volume":"85","author":"Saito S.","year":"2021","journal-title":"Circulation Journal"},{"issue":"12","key":"e_1_2_11_6_1","first-page":"1337","article-title":"Intravascular Lithotripsy for Treatment of Calcified Coronary Lesions","volume":"14","author":"Kereiakes D. J.","year":"2021","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"15","key":"e_1_2_11_7_1","first-page":"1811","article-title":"Contemporary Trends and Outcomes of Intravascular Lithotripsy in Percutaneous Coronary Intervention","volume":"17","author":"Sukul D.","year":"2024","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"2","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/ccd.31637","article-title":"Comparison of Procedural and Clinical Outcomes of Angiography\u2010 Versus Imaging\u2010Guided Percutaneous Coronary Intervention With Intravascular Lithotripsy","volume":"106","author":"Phagu A. A. 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