{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:09:06Z","timestamp":1790140146503,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biodegradable\u2010polymer (BP) drug\u2010eluting stents (DES) were developed to mitigate potential late adverse events related to persistent durable polymers in durable\u2010polymer (DP) DES; however, contemporary long\u2010term real\u2010world comparative data remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to compare the 5\u2010year clinical outcomes of contemporary BP\u2010DES and DP\u2010DES in patients undergoing routine percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed consecutive patients undergoing PCI with second\u2010generation or newer DES at a single institution (2010\u20132021). Propensity scores were estimated using prespecified clinical, angiographic, and procedural covariates, and 1:1 nearest\u2010neighbor matching was performed. The primary endpoint was 5\u2010year target lesion failure (TLF: cardiac death, target vessel myocardial infarction [TV\u2010MI], or clinically driven target lesion revascularization [TLR]). Key secondary endpoints were 1\u2010year TLF, all\u2010cause mortality, and ARC\u20102 definite or probable stent thrombosis. A prespecified 1\u2010year landmark analysis evaluated outcomes from 0 to 1 and 1 to 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, 2197 pairs (4394 patients) were included. At 5 years, TLF occurred in 7.9% of BP\u2010DES and 7.9% of DP\u2010DES patients (HR 1.01, 95% CI 0.81\u20131.26;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.936). No statistically significant differences were observed in secondary endpoints, including 1\u2010year TLF, individual TLF components, all\u2010cause mortality, or ARC\u20102 definite or probable stent thrombosis. All\u2010cause mortality at 5 years was similar between groups (7.1% vs. 8.2%; HR 0.87, 95% CI 0.69\u20131.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.213); however, in the 1\u20135\u2010year landmark period, mortality was numerically lower with BP\u2010DES (HR 0.73, 95% CI 0.53\u20131.00; nominal\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047). No significant treatment\u2010by\u2010subgroup interactions were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In routine PCI using second\u2010generation or newer DES, BP\u2010DES and DP\u2010DES demonstrated comparable 5\u2010year TLF. The potential late survival signal with BP\u2010DES is hypothesis\u2010generating and should be interpreted cautiously given the observational design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70878","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:57:42Z","timestamp":1790139462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Five\u2010Year Clinical Outcomes of Biodegradable Versus Durable Polymer Drug\u2010Eluting Stents: A Propensity Score\u2010Matched Analysis of 4394 Patients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9228-4006","authenticated-orcid":false,"given":"Yangyoun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Cardiology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-2071","authenticated-orcid":false,"given":"Hong\u2010Seok","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-9215","authenticated-orcid":false,"given":"Kyoung\u2010Woo","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-9772","authenticated-orcid":false,"given":"Hyoung\u2010Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-7892","authenticated-orcid":false,"given":"So\u2010Yeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-178X","authenticated-orcid":false,"given":"Seung\u2010Jea","family":"Tahk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-8594","authenticated-orcid":false,"given":"Myeong\u2010Ho","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"23","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJMoa012843","article-title":"A Randomized Comparison of a Sirolimus\u2010Eluting Stent With a Standard Stent for Coronary Revascularization","volume":"346","author":"Morice M. C.","year":"2002","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2006.03.042","article-title":"Pathology of Drug\u2010Eluting Stents in Humans","volume":"48","author":"Joner M.","year":"2006","journal-title":"Journal of the American College of Cardiology"},{"issue":"2","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3390\/ma7020769","article-title":"Biocompatibility of Coronary Stents","volume":"7","author":"Jeewandara T.","year":"2014","journal-title":"Materials"},{"issue":"2","key":"e_1_2_13_5_1","first-page":"139","article-title":"Current State of Bioabsorbable Polymer\u2010Coated Drug\u2010Eluting Stents","volume":"13","author":"Akinapelli A.","year":"2017","journal-title":"Current Cardiology Reviews"},{"issue":"2","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/CIRCULATIONAHA.116.021539","article-title":"Bioresorbable Vascular Scaffolds for Coronary Revascularization","volume":"134","author":"Kereiakes D. J.","year":"2016","journal-title":"Circulation"},{"issue":"5","key":"e_1_2_13_7_1","first-page":"462","article-title":"Meta\u2010Analysis of Randomized Clinical Trials Comparing Biodegradable Polymer Drug\u2010Eluting Stent to Second\u2010Generation Durable Polymer Drug\u2010Eluting Stents","volume":"10","author":"El\u2010Hayek G.","year":"2017","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"3","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12928-019-00613-w","article-title":"Five\u2010Year Clinical Efficacy and Safety of Contemporary Thin\u2010Strut Biodegradable Polymer Versus Durable Polymer Drug\u2010Eluting Stents: A Systematic Review and Meta\u2010Analysis of 9 Randomized Controlled Trials","volume":"35","author":"Kobayashi T.","year":"2020","journal-title":"Cardiovascular Intervention and Therapeutics"},{"issue":"6","key":"e_1_2_13_9_1","first-page":"639","article-title":"Biodegradable\u2010 Versus Durable\u2010Polymer Drug\u2010Eluting Stents for STEMI","volume":"14","author":"Pilgrim T.","year":"2021","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"24","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/eurheartj\/ehz074","article-title":"Five\u2010Year Clinical Outcomes and Intracoronary Imaging Findings of the COMFORTABLE AMI Trial: Randomized Comparison of Biodegradable Polymer\u2010Based Biolimus\u2010Eluting Stents With Bare\u2010Metal Stents in Patients With Acute ST\u2010Segment Elevation Myocardial Infarction","volume":"40","author":"R\u00e4ber L.","year":"2019","journal-title":"European Heart Journal"},{"issue":"1","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1586\/14779072.2016.1112267","article-title":"Drug\u2010Eluting Stents to Prevent Stent Thrombosis and Restenosis","volume":"14","author":"Im E.","year":"2016","journal-title":"Expert Review of Cardiovascular Therapy"},{"issue":"16","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4244\/EIJ-D-17-00728","article-title":"Acute Thrombogenicity of Fluoropolymer\u2010Coated Versus Biodegradable and Polymer\u2010Free Stents","volume":"14","author":"Torii S.","year":"2019","journal-title":"EuroIntervention"},{"issue":"10","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.4244\/EIJ-D-18-00434","article-title":"Characteristics of National and Major Regional Percutaneous Coronary Intervention Registries: A Structured Literature Review","volume":"14","author":"Biswas S.","year":"2018","journal-title":"EuroIntervention"},{"issue":"8","key":"e_1_2_13_14_1","first-page":"777","article-title":"Improved Safety and Reduction in Stent Thrombosis Associated With Biodegradable Polymer\u2010Based Biolimus\u2010Eluting Stents Versus Durable Polymer\u2010Based Sirolimus\u2010Eluting Stents in Patients With Coronary Artery Disease: Final 5\u2010Year Report of the LEADERS (Limus Eluted From A Durable Versus ERodable Stent Coating) Randomized, Noninferiority Trial","volume":"6","author":"Serruys P. W.","year":"2013","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"10149","key":"e_1_2_13_15_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0140-6736(18)31715-X","article-title":"Ultrathin\u2010Strut, Biodegradable\u2010Polymer, Sirolimus\u2010Eluting Stents Versus Thin\u2010Strut, Durable\u2010Polymer, Everolimus\u2010Eluting Stents for Percutaneous Coronary Revascularisation: 5\u2010Year Outcomes of the BIOSCIENCE Randomised Trial","volume":"392","author":"Pilgrim T.","year":"2018","journal-title":"Lancet"},{"issue":"10","key":"e_1_2_13_16_1","article-title":"Final 3\u2010Year Outcome of a Randomized Trial Comparing Second\u2010Generation Drug\u2010Eluting Stents Using Either Biodegradable Polymer or Durable Polymer: NOBORI Biolimus\u2010Eluting Versus XIENCE\/PROMUS Everolimus\u2010Eluting Stent Trial","volume":"8","author":"Natsuaki M.","year":"2015","journal-title":"Circulation: Cardiovascular Interventions"},{"issue":"18","key":"e_1_2_13_17_1","first-page":"1852","article-title":"Ultrathin Bioresorbable Polymer Sirolimus\u2010Eluting Stents Versus Durable Polymer Everolimus\u2010Eluting Stents","volume":"15","author":"Kandzari D. E.","year":"2022","journal-title":"JACC: Cardiovascular Interventions"},{"issue":"4","key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jacc.2013.09.061","article-title":"Clinical Outcomes With Bioabsorbable Polymer\u2010 Versus Durable Polymer\u2010Based Drug\u2010Eluting and Bare\u2010Metal Stents","volume":"63","author":"Palmerini T.","year":"2014","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"e_1_2_13_19_1","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2024-003104","article-title":"Durable Versus Biodegradable Polymer Drug\u2010Eluting Stents in All\u2010Comers","volume":"12","author":"Witzig T.","year":"2025","journal-title":"Open Heart"},{"issue":"14","key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jacc.2008.07.006","article-title":"Incidence and Correlates of Drug\u2010Eluting Stent Thrombosis in Routine Clinical Practice","volume":"52","author":"Wenaweser P.","year":"2008","journal-title":"Journal of the American College of Cardiology"},{"issue":"9562","key":"e_1_2_13_21_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0140-6736(07)60314-6","article-title":"Early and Late Coronary Stent Thrombosis of Sirolimus\u2010Eluting and Paclitaxel\u2010Eluting Stents in Routine Clinical Practice: Data From a Large Two\u2010Institutional Cohort Study","volume":"369","author":"Daemen J.","year":"2007","journal-title":"Lancet"},{"issue":"13","key":"e_1_2_13_22_1","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/CIRCULATIONAHA.110.003210","article-title":"Stent Thrombogenicity Early in High\u2010Risk Interventional Settings Is Driven by Stent Design and Deployment and Protected by Polymer\u2010Drug Coatings","volume":"123","author":"Kolandaivelu K.","year":"2011","journal-title":"Circulation"},{"issue":"2","key":"e_1_2_13_23_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.17925\/HI.2021.15.2.84","article-title":"A Narrative Review of Ultrathin\u2010Strut Drug\u2010Eluting Stents: The Thinner the Better?","volume":"15","author":"Grundeken M. J.","year":"2021","journal-title":"Heart International"},{"issue":"20","key":"e_1_2_13_24_1","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1161\/CIRCULATIONAHA.118.034456","article-title":"Newer\u2010Generation Ultrathin Strut Drug\u2010Eluting Stents Versus Older Second\u2010Generation Thicker Strut Drug\u2010Eluting Stents for Coronary Artery Disease","volume":"138","author":"Bangalore S.","year":"2018","journal-title":"Circulation"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70878","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:57:45Z","timestamp":1790139465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":23,"alternative-id":["10.1002\/ccd.70878"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70878","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"assertion":[{"value":"2026-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ccd.70878"}}