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Persistent LAA thrombi despite being on therapeutic anticoagulation is not uncommon, and management of such thrombus is challenging. A novel strategy for such patients is mechanical thrombectomy and LAA occlusion device placement along with cerebral protection device deployment. Nevertheless, further investigation is needed to validate this emerging strategy.<\/jats:p>","DOI":"10.1002\/ccd.70899","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:37:10Z","timestamp":1789706230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical Thrombectomy With Cerebral Protection Device for Persistent Left Atrial Appendage Thrombus: A Case Report With Literature Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3134-5055","authenticated-orcid":false,"given":"Sameer","family":"Acharya","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cayuga Medical Center Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Umar","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rochester General Hospital, Section of Cardiovascular Medicine Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Fiema","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rochester General Hospital, Section of Cardiovascular Medicine Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah","family":"Depta","sequence":"additional","affiliation":[{"name":"Department of Medicine Medical College of Wisconsin, Division of Cardiovascular Medicine Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022274"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23956"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(21)01737-x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.09.027"},{"issue":"3","key":"e_1_2_7_6_1","article-title":"Surgical Removal of Left Atrial Appendage Thrombus in a Patient With Acute Ischemic Stroke","volume":"2","author":"Cho J. 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