{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:03:17Z","timestamp":1790002997671,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with large aortic annuli are a more challenging subgroup for transcatheter aortic valve implantation (TAVI), and data on long\u2010term outcomes are sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Compare outcomes of patients with large annular anatomies to outcomes of patients with regular anatomies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between January 2015 and November 2025, 488 patients underwent TAVI with different generations of Evolut valves for the treatment of native aortic stenosis. Outcomes of large 34\u2009mm valves were compared to regular size 23\u221229 mm valves. To account for the nonrandomized design, the primary comparison was performed in a 1:1 propensity score matching cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 186 (38%) patients received large and 302 (62%) received regular size valves. Propensity score matching yielded 141 well\u2010balanced pairs, in whom age (80 \u00b1 6 vs. 81 \u00b1 6 years), STS\u2010PROM score (3.2 [2.0\u22124.9] vs. 3.6 [2.1\u22125.8]), and male sex (96% vs. 97%), were comparable. Procedural technical success (95% vs. 94%), device success (90% vs. 92%), and early safety (79% vs. 79%) were comparable. At 30 days, mortality (2.1% vs. 1.4%), stroke (2.1% vs. 3.5%), and new pacemaker implantation (12% vs. 11%) did not differ significantly. At 5 years, there were no significant differences between the groups in all\u2010cause mortality (HR 1.06, 95% CI 0.64\u20131.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8), stroke (sHR 0.74, 95% CI 0.26\u22122.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.6), heart failure rehospitalization (sHR 0.96, 95% CI 0.46\u22122.01,\n                      <jats:italic>p<\/jats:italic>\n                      =0.9), or new pacemaker implantation (sHR 1.02, 95% CI 0.57\u22121.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9). Structural valve deterioration stage 3 (0% vs. 1.6%), infective endocarditis (1.7% vs. 2.8%), and valve reintervention (0% vs. 0.9%) were infrequent in both groups. The findings were consistent in the whole\u2010cohort analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Outcomes after TAVI with large self\u2010expanding valves were comparable to regular size valves, demonstrating favorable results up to 5 years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70900","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:19:37Z","timestamp":1790000377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010 and Long\u2010Term Outcomes After Transcatheter Aortic Valve Implantation With Large Self\u2010Expanding Valves"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3481-8662","authenticated-orcid":false,"given":"Polyxeni","family":"Alexiou","sequence":"first","affiliation":[{"name":"Heart Center Lucerne, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-5676","authenticated-orcid":false,"given":"Federico","family":"Moccetti","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7510-7062","authenticated-orcid":false,"given":"Stephanie","family":"Brunner","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7514-0808","authenticated-orcid":false,"given":"Nina","family":"Conrad","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-0128","authenticated-orcid":false,"given":"Mathias","family":"Wolfrum","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-0298","authenticated-orcid":false,"given":"Stefan","family":"Toggweiler","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Luzerner Kantonsspital Lucerne 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