{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:11:37Z","timestamp":1790691097287,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Contrast\u2010induced acute kidney injury (CI\u2010AKI) frequently complicates primary percutaneous coronary intervention (PCI) in patients with ST\u2010segment elevation myocardial infarction (STEMI). The no\u2010reflow phenomenon, a primary cause of inadequate reperfusion, is linked to systemic inflammation and CI\u2010AKI development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the association between no\u2010reflow and CI\u2010AKI, and the subsequent impact on short\u2010 and long\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study included 299 STEMI patients undergoing primary PCI. CI\u2010AKI was defined as a serum creatinine increase \u2265\u200925% or \u22650.5\u2009mg\/dL within 48\u201372\u2009h post\u2010contrast. No\u2010reflow was diagnosed if final distal flow was &lt;TIMI III and\/or myocardial blush was absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CI\u2010AKI occurred in 14.04% (42 patients). These patients were older, had higher inflammatory markers (WBC, CRP), and lower left ventricular ejection fraction. The incidence of no\u2010reflow was significantly higher in the CI\u2010AKI group (73.8% vs. 15.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate analysis identified the no\u2010reflow phenomenon as an independent predictor of CI\u2010AKI (OR: 10.925, 95% CI: 3.709\u201332.181,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Furthermore, all\u2010cause mortality was significantly higher in patients with CI\u2010AKI (21.4% vs. 7.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), and CI\u2010AKI was independently associated with poor long\u2010term survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The no\u2010reflow phenomenon is a strong, independent predictor of CI\u2010AKI following primary PCI in STEMI patients. Additionally, CI\u2010AKI is independently associated with increased short\u2010 and long\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70904","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:46:52Z","timestamp":1790689612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The No\u2010Reflow Phenomenon as an Independent Predictor of Contrast\u2010Induced Acute Kidney Injury and Mortality in STEMI Patients Undergoing Primary PCI"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-1044","authenticated-orcid":false,"given":"Utku","family":"Raimoglu","sequence":"first","affiliation":[{"name":"Yedikule Surp Pirgic Armenian Hospital Foundation Istanbul 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-1956","authenticated-orcid":false,"given":"Ali Ugur","family":"Soysal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Istanbul University\u2010Cerrahpasa, Cerrahpasa Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebnem","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Istanbul University\u2010Cerrahpasa, Cerrahpasa Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6265-2122","authenticated-orcid":false,"given":"Alpin Mert","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Istanbul University\u2010Cerrahpasa, Cerrahpasa Medical School Istanbul 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