{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:56:50Z","timestamp":1790567810242,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470340"],"award-info":[{"award-number":["82470340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In\u2010stent restenosis (ISR) after percutaneous coronary interventions (PCI) remains a significant challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the predictive ability of coronary CT angiography (CTA) derived plaque and hemodynamic characteristics for ISR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we included stable patients who underwent coronary CTA prior to the index PCI and subsequently exhibited both ISR and non\u2010ISR in different stented lesions during follow\u2010up. The plaque and hemodynamic characteristics derived from coronary CTA were assessed. The incremental discriminant and reclassification abilities for ISR prediction were compared among 2 models (model 1: procedural characteristics; model 2: model 1 + plaque characteristics + hemodynamic characteristics).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 52 patients with 120 lesions were included in the study, comprising 63 ISR lesions and 57 non\u2010ISR lesions. The average age was 62.6\u2009\u00b1\u20099.9 years old and 67.3% (35\/52) were male. The median interval between index PCI and ISR was 22 (14.3\u221266.8) months. Compared with non\u2010ISR group, lesions in ISR group exhibited more adverse plaque characteristics (APC) and adverse hemodynamic characteristics (AHC). The risk of developing ISR in lesions with \u2265\u20092 APC and \u2265\u20093 AHC was significantly higher than that with &lt;\u20092 APC and &lt;\u20093 AHC (HR\u2009=\u200911.02, 95% CI\u2009=\u20091.63\u221216.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The C\u2010index of Model 2 (0.858; 95% CI: 0.782\u20130.925) was higher than that of Model 1 (0.762; 95% CI: 0.670\u20130.845) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The noninvasive assessment of CTA\u2010derived plaque characteristics and hemodynamic features enhanced the prediction of ISR after PCI in stable patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70908","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:26:01Z","timestamp":1790565961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coronary CT Angiography\u2010Derived Plaque and Hemodynamic Characteristics for In\u2010Stent Restenosis: A Self\u2010Controlled Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5043-6692","authenticated-orcid":false,"given":"Wei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Health Science and Engineering University of Shanghai for Science and Technology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital Fudan University Shanghai China"},{"name":"Shanghai Institute of Medical Imaging Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingpu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rende","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatian","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-3692","authenticated-orcid":false,"given":"Juying","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9939-4817","authenticated-orcid":false,"given":"Chenguang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-7332","authenticated-orcid":false,"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases Fudan University Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jacc.2022.05.017","article-title":"Coronary In\u2010Stent Restenosis","volume":"80","author":"Giustino G.","year":"2022","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"e380","DOI":"10.4244\/EIJ-D-19-01031","article-title":"Long\u2010Term Outcomes of Percutaneous 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A Critical Review of Clinical Data on Shear Stress After Intracoronary Stent Implantation","volume":"23","author":"Jenei C.","year":"2016","journal-title":"Cardiology Journal"},{"key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s10554-016-1003-0","article-title":"Assessment of Endothelial Shear Stress in Patients With Mild or Intermediate Coronary Stenoses Using Coronary Computed Tomography Angiography: Comparison With Invasive Coronary Angiography","volume":"33","author":"Huang D.","year":"2017","journal-title":"International Journal of Cardiovascular Imaging"},{"key":"e_1_2_12_30_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jcct.2023.03.009","article-title":"Endothelial Shear Stress Computed From Coronary Computed Tomography Angiography: A Direct Comparison to Intravascular Ultrasound","volume":"17","author":"Hakim D.","year":"2023","journal-title":"Journal of Cardiovascular Computed Tomography"},{"key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s10439-020-02631-9","article-title":"Validation of Wall Shear Stress Assessment in Non\u2010Invasive Coronary CTA Versus Invasive Imaging: A Patient\u2010Specific Computational Study","volume":"49","author":"Eslami P.","year":"2021","journal-title":"Annals of Biomedical Engineering"},{"key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/j.jacc.2019.02.060","article-title":"Prognostic Implications of Plaque Characteristics and Stenosis Severity in Patients With Coronary Artery Disease","volume":"73","author":"Lee J. 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