{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:00:46Z","timestamp":1790164846172,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal treatment for isolated side\u2010branch coronary bifurcation lesions (Medina 0.0.1) remains debated. Drug\u2010coated balloons (DCB) offer a \u201cleave\u2010nothing\u2010behind\u201d alternative to drug\u2010eluting stents (DES), but comparative data for this specific lesion subset is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to compare the 1\u2010year clinical and angiographic outcomes of a DCB strategy versus a contemporary stenting strategy for Medina 0.0.1 lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, observational cohort study enrolled 161 patients with symptomatic ischemic heart disease and de novo Medina 0.0.1 bifurcation lesions. Patients were allocated to either a stenting strategy (Group A,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200980) or a DCB strategy (Group B,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200981) based on operator judgment. The primary endpoints were absolute late lumen loss (LLL), binary restenosis, target vessel revascularization (TVR), and a five\u2010point composite of major adverse cardiac events (MACE) at 1\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were comparable between the two groups. At 1 year, the mean late lumen loss (LLL) was significantly lower in the DCB group compared with the stenting group (0.16\u2009\u00b1\u20090.12\u2009mm vs. 0.48\u2009\u00b1\u20090.22\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The DCB group demonstrated a significantly lower rate of binary restenosis compared with the stenting group (7.4% vs. 21.3%; RR 0.35, 95% CI 0.15\u20130.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014; ARR 13.9%; NNT 7). TVR was significantly reduced in the DCB group (4.9% vs. 15.0%; RR 0.33, 95% CI 0.11\u20130.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038; ARR 10.1%; NNT 10). The incidence of MACE was also markedly lower in the DCB group (7.4% vs. 18.7%; RR 0.40, 95% CI 0.17\u20130.93;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043; ARR 11.3%; NNT 9), primarily attributed to the reduction in TVR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with isolated Medina 0.0.1 bifurcation lesions, a DCB strategy following successful lesion preparation was associated with favorable angiographic and clinical outcomes at 1 year compared with a stenting strategy, including lower late lumen loss, reduced angiographic restenosis and repeat revascularization, and a lower incidence of MACE, driven primarily by fewer repeat revascularization events. However, because treatment allocation was largely determined by predilation response, these findings did not establish the comparative superiority of DCB over DES.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70919","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:09:03Z","timestamp":1790161743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Coated Balloon Versus Stenting for Medina 0.0.1 Coronary Bifurcation Lesions: One\u2010Year Clinical and Angiographic Outcomes of a Leave\u2010Nothing\u2010Behind Strategy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4563-1276","authenticated-orcid":false,"given":"Ayman Ahmed","family":"Gad","sequence":"first","affiliation":[{"name":"Department of Cardiology Faculty of Medicine, Al Azhar University New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Mohamed Ahmed Kamal","family":"Hal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine, Al Azhar University New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa Ebrahim","family":"Mokarrab","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine, Al Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Adel","family":"Attia","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine, Al Azhar University New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-9873","authenticated-orcid":false,"given":"Khaled","family":"Abouelmagd","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine, Al Azhar University New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2917-3632","authenticated-orcid":false,"given":"Waseem Omar","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine, Al Azhar University New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-25-00201"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.36469\/9746"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025459;WGROUP:STRING:PUBLICATION"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJCHA.2023.101311"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.15420\/ICR.2020.30"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCIN.2023.06.013"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJCARD.2024.132863"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.121.010868;WEBSITE:WEBSITE:AHA-SITE;WGROUP:STRING:PUBLICATION"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.14744\/ANATOLJCARDIOL.2025.5296"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCIN.2023.08.033;CTYPE:STRING:JOURNAL"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I7A136"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2025.09.059"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.31083\/J.RCM2512446"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACASI.2025.02.017;SUBPAGE:STRING:FULL"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscai.2025.103944"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACC.2025.09.485"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2026.134621"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/JCDD12100410"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2024.12.025"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00392-025-02700-W"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.08.067"}],"container-title":["Catheterization 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