{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:48:11Z","timestamp":1792054091430,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Renal denervation (RDN) is an adjunctive treatment for selected patients with resistant hypertension. We report the preliminary effectiveness and safety of radiofrequency RDN in a high\u2010risk real\u2010world population. This prospective, observational, single\u2010center study enrolled 18 patients who underwent bilateral RDN using the Symplicity Spyral system. All had baseline office systolic BP (SBP)\u2009&gt;\u2009155\u2009mmHg and diastolic BP\u2009&gt;\u200990\u2009mmHg despite at least three antihypertensive drugs at the maximum tolerated doses. Clinical response required both an office SBP reduction \u2265\u200910\u2009mm Hg and a mean 24\u2010h ambulatory SBP reduction \u2265\u20095\u2009mm Hg. Outcomes were assessed within 72\u2009h and at 1 month. All procedures were technically successful. At 72\u2009h, 15 patients (83.3%) met both response criteria; all had an office SBP reduction \u2265\u200920\u2009mm Hg. At 1 month, 16 (88.9%) were responders and 2 (11.1%) were nonresponders. Among responders, five discontinued one drug and continued dual therapy, whereas 11 continued three drugs at reduced doses. Procedural events included one iatrogenic renal artery dissection, one femoral artery dissection with perforation, one guidewire fracture successfully retrieved with an endovascular snare, and two femoral hematomas. Renal function did not deteriorate. In conclusion, radiofrequency RDN was technically feasible and was followed by an early clinical response in most patients. The small sample, short follow\u2010up, and absence of a control group preclude definitive efficacy conclusions.<\/jats:p>","DOI":"10.1002\/ccd.70920","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:20:10Z","timestamp":1792052410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Percutaneous Renal Denervation for Resistant Hypertension in a High\u2010Risk Real\u2010World Population: Preliminary Results From a Prospective Single\u2010Center Experience"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4274-3810","authenticated-orcid":false,"given":"Saverio Danilo","family":"Vetrano","sequence":"first","affiliation":[{"name":"U.O.C. Cardiologia Interventistica, A.O.R.N. \u201cSan Pio\u201d Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Formigli","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Interventistica, A.O.R.N. \u201cSan Pio\u201d Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3094-4121","authenticated-orcid":false,"given":"Luciano Umberto","family":"Rossi","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Interventistica, A.O.R.N. \u201cSan Pio\u201d Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Marco","family":"Esposito","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Interventistica, A.O.R.N. \u201cSan Pio\u201d Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Covino","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Interventistica, A.O.R.N. \u201cSan Pio\u201d Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Moscato","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Interventistica, A.O.R.N. \u201cSan Pio\u201d Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitangelo","family":"Franco","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Interventistica, A.O.R.N. \u201cSan Pio\u201d Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Scherillo","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Interventistica, A.O.R.N. \u201cSan Pio\u201d Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad054"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30554-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00455-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.0713"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz118"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab154"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.21972"},{"key":"e_1_2_8_11_1","volume-title":"ICH Harmonised Guideline E6(R2): Guideline for Good Clinical Practice","author":"ICH Harmonised Guideline","year":"2016"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70920","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:20:12Z","timestamp":1792052412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":10,"alternative-id":["10.1002\/ccd.70920"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70920","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"2026-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ccd.70920"}}