{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:59:42Z","timestamp":1790744382769,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370483"],"award-info":[{"award-number":["82370483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400562"],"award-info":[{"award-number":["82400562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of transcatheter (TAVR) versus surgical aortic valve replacement (SAVR) on multi\u2010dimensional anti\u2011cancer therapy continuity and survival in cancer patients with severe aortic stenosis (AS) remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess whether TAVR, compared with SAVR, is associated with superior anti\u2010cancer therapy continuity and survival in cancer patients with severe AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study of cancer patients undergoing TAVR or SAVR for severe AS from June 2018 to December 2024. Inverse probability of treatment weighting (IPTW) was used. Endpoints included 90\u2011day therapy resumption (primary; Fine\u2212Gray competing risk regression), 1\u2011year completion, cardiac\u2011related interruptions, and mortality. Sensitivity, landmark, and dose\u2212response analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 183 patients (TAVR: 101, SAVR: 82), IPTW achieved excellent balance. TAVR was associated with higher 90\u2011day resumption (83.7% vs. 56.3%; OR 3.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and shorter time to resumption (28 vs. 75 days; sHR 2.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A dose\u2212response relationship was observed: each 30\u2011day delay increased cancer mortality by 15% (HR 1.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). TAVR reduced non\u2011fatal cardiac\u2011related interruptions (6.9% vs. 17.1%; OR 0.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Therapy interruption independently predicted all\u2011cause mortality (HR 1.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), even after excluding progression\u2011related interruptions (sensitivity HR 1.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Landmark analysis at 3 months showed better subsequent survival with early resumption (HR 0.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Benefits were most pronounced in neoadjuvant patients (interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Competing risk analysis showed lower 3\u2011year cardiovascular mortality with TAVR (4% vs. 12%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TAVR was associated with superior therapy continuity and fewer cardiac interruptions. A dose\u2011dependent association between treatment delay and cancer mortality was observed. These findings suggest that TAVR may be preferred in patients requiring timely neoadjuvant therapy, but prospective validation is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70924","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:37:17Z","timestamp":1790743037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter Aortic Valve Replacement Facilitates Anti\u2010Cancer Therapy Continuity and Improves Survival in Cancer Patients"],"prefix":"10.1002","author":[{"given":"Hua\u2010Jie","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Ling","family":"Zeng","sequence":"additional","affiliation":[{"name":"Outpatient Department Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Han","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San\u2010Jiu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Nan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Prevention and Healthcare Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8908-5490","authenticated-orcid":false,"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"12","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41569-021-00570-z","article-title":"Global Epidemiology of Valvular Heart Disease","volume":"18","author":"Coffey S.","year":"2021","journal-title":"Nature Reviews Cardiology"},{"issue":"3","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s00392-024-02465-8","article-title":"Natural History of Initially Asymptomatic Severe Aortic Stenosis: A One\u2010Stage Meta\u2010Analysis","volume":"114","author":"Tan J. T. A.","year":"2025","journal-title":"Clinical Research in Cardiology"},{"issue":"16","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1161\/CIRCULATIONAHA.118.035514","article-title":"Outcomes of Patients With Mediastinal Radiation\u2010Associated Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement","volume":"138","author":"Donnellan E.","year":"2018","journal-title":"Circulation"},{"issue":"3","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/ccd.28052","article-title":"An Update on the Management and Outcomes of Cancer Patients With Severe Aortic Stenosis","volume":"94","author":"Schechter M.","year":"2019","journal-title":"Catheterization and Cardiovascular Interventions: Official Journal of the Society for Cardiac Angiography & Interventions"},{"issue":"20","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1136\/heartjnl-2022-321396","article-title":"Transcatheter Aortic Valve Intervention in Patients With Cancer","volume":"109","author":"Leedy D.","year":"2023","journal-title":"Heart"},{"issue":"3","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","DOI":"10.1002\/clc.70121","article-title":"Clinical Outcomes and Prognostic Implications of TAVR in Patients With Active Cancer: A Meta\u2010Analysis","volume":"48","author":"Saberian P.","year":"2025","journal-title":"Clinical Cardiology"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcha.2024.101410","article-title":"Impact of Cancer in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta\u2010Analysis","volume":"52","author":"Osawa T.","year":"2024","journal-title":"International Journal of Cardiology. Heart & Vasculature"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijcard.2020.08.071","article-title":"Transcatheter and Surgical Aortic Valve Replacement Impact on Outcomes and Cancer Treatment Schedule","volume":"326","author":"Gill C.","year":"2021","journal-title":"International Journal of Cardiology"},{"issue":"10","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00392-020-01615-y","article-title":"Prognostic Impact of Cancer History in Patients Undergoing Transcatheter Aortic Valve Implantation","volume":"109","author":"Tabata N.","year":"2020","journal-title":"Clinical Research in Cardiology"},{"issue":"1","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s40959-024-00256-8","article-title":"Outcomes of Patients With Active Cancer After Transcatheter Aortic Valve Replacement: An Updated Meta\u2010Analysis","volume":"10","author":"Felix N.","year":"2024","journal-title":"Cardio\u2010Oncology"},{"issue":"7","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the Management of Valvular Heart Disease","volume":"43","author":"Vahanian A.","year":"2022","journal-title":"European Heart Journal"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2025.134137","article-title":"Transcatheter Aortic Valve Replacement in Patients With Cancer: A 10\u2010Year Registry Analysis of Early and Long\u2010Term Mortality Outcomes","volume":"447","author":"Kheifets M.","year":"2026","journal-title":"International Journal of Cardiology"},{"issue":"1","key":"e_1_2_12_14_1","article-title":"Trends and Outcomes of TAVI and SAVR? in Cancer and Noncancer Patients","volume":"2","author":"Ullah W.","year":"2023","journal-title":"JACC: Advances"},{"issue":"1","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2023-002573","article-title":"Midterm Outcomes of Transcatheter Aortic Valve Replacement in Patients With Active Cancer","volume":"11","author":"Noguchi M.","year":"2024","journal-title":"Open Heart"},{"issue":"11","key":"e_1_2_12_16_1","article-title":"Outcomes and Adverse Effects of Transcatheter Aortic Valve Replacement (TAVR) in Cancer Patients: A Meta\u2010Analysis","volume":"16","author":"Ahsan U.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.763557","article-title":"Association Between Previous or Active Cancer and Clinical Outcomes in TAVR Patients: A Systematic Review and Meta\u2010Analysis of 255,840 Patients","volume":"8","author":"Diaz\u2010Arocutipa C.","year":"2021","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"41","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC Guidelines on Cardio\u2010Oncology Developed in Collaboration With the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio\u2010Oncology Society (IC\u2010OS)","volume":"43","author":"Lyon A. 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U.","year":"2024","journal-title":"JCO Global Oncology"},{"issue":"13","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3390\/cancers17132076","article-title":"The Impact of Treatment Delay on Endometrial and Ovarian Cancer Patients: A Systematic Review","volume":"17","author":"Zouzoulas D.","year":"2025","journal-title":"Cancers"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70924","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:37:23Z","timestamp":1790743043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":23,"alternative-id":["10.1002\/ccd.70924"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70924","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ccd.70924"}}