{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:56:54Z","timestamp":1790747814175,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Massive pulmonary artery thrombosis in neonates is rare and frequently fatal when associated with right ventricular failure and hemodynamic collapse. We report a premature neonate with extensive inferior vena cava, right ventricular outflow tract, and bilateral pulmonary artery thrombosis resulting in respiratory failure requiring venoarterial extracorporeal membrane oxygenation. Progressive thrombus burden despite systemic anticoagulation prompted catheter\u2010directed mechanical aspiration thrombectomy using escalating aspiration systems with adjunctive localized thrombolysis. Significant resolution of the thrombus was achieved with restoration of pulmonary blood flow and improvement in right ventricular function. This case demonstrates the feasibility of ECMO\u2010supported aspiration thrombectomy as a life\u2010saving strategy for neonatal thromboembolic disease.<\/jats:p>","DOI":"10.1002\/ccd.70926","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:03:34Z","timestamp":1790744614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracorporeal Membrane Oxygenation\u2010Supported Aspiration Thrombectomy and Catheter\u2010Directed Thrombolysis for Massive Pulmonary Artery and Inferior Vena Cava Thrombosis in a Neonate"],"prefix":"10.1002","author":[{"given":"Karunakar","family":"Vadalmudi","sequence":"first","affiliation":[{"name":"Golisano Children's Hospital University of Rochester Medicine Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3780-8254","authenticated-orcid":false,"given":"Hope","family":"Kile","sequence":"additional","affiliation":[{"name":"Golisano Children's Hospital University of Rochester Medicine Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Leonard","sequence":"additional","affiliation":[{"name":"Golisano Children's Hospital University of Rochester Medicine Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-9988","authenticated-orcid":false,"given":"George A.","family":"Porter","sequence":"additional","affiliation":[{"name":"Golisano Children's Hospital University of Rochester Medicine Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V120.21.1009.1009","article-title":"Blood Flow is Increased in Wounds and Peri\u2010Wound Area by Laser Speckle Contrast Imaging and Infrared Thermography in Adults With Sickle Cell Leg Ulcers","volume":"120","author":"Delaney K. M.","year":"2012","journal-title":"Blood"},{"issue":"3","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/S2352-3026(18)30224-2","article-title":"Outcomes and Risk Factors of Massive and Submassive Pulmonary Embolism in Children: A Retrospective Cohort Study","volume":"6","author":"Pelland\u2010Marcotte M.\u2010C.","year":"2019","journal-title":"Lancet Haematology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2141.2010.08543.x","article-title":"Guideline on the Investigation, Management and Prevention of Venous Thrombosis in Children","volume":"154","author":"Chalmers E.","year":"2011","journal-title":"British Journal of Haematology"},{"key":"e_1_2_8_5_1","first-page":"143","article-title":"Catheter\u2010Directed Therapy for Pulmonary Embolism: Systematic Review","volume":"26","author":"Kuo W. T.","year":"2015","journal-title":"Journal of Vascular and Interventional Radiology"},{"key":"e_1_2_8_6_1","first-page":"146","article-title":"Mechanical Thrombectomy for Pulmonary Embolism in Pediatric Patients","volume":"96","author":"Khan M. S.","year":"2020","journal-title":"Catheterization and Cardiovascular Interventions"},{"key":"e_1_2_8_7_1","first-page":"2029","article-title":"Contemporary Management of Pediatric Pulmonary Embolism","volume":"138","author":"Avila M. L.","year":"2018","journal-title":"Circulation"},{"issue":"3","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S1047951118002135","article-title":"Catheter\u2010Directed Therapy for Acute Pulmonary Embolism in Children","volume":"29","author":"Akam\u2010Venkata J.","year":"2019","journal-title":"Cardiology in the Young"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70926","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:03:36Z","timestamp":1790744616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":7,"alternative-id":["10.1002\/ccd.70926"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70926","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ccd.70926"}}