{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:58:07Z","timestamp":1790744287549,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015825","name":"Korea University Anam Hospital","doi-asserted-by":"publisher","award":["O2514211"],"award-info":[{"award-number":["O2514211"]}],"id":[{"id":"10.13039\/501100015825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>RFR has shown good aggregate agreement with FFR, including in prior Asian cohorts using intracoronary nicorandil. Where RFR\u2010FFR disagreement is concentrated relative to the FFR 0.80 decision boundary, and how the two binary thresholds correspond, remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective single\u2010center registry, 300 patients (399 lesions) underwent sequential RFR and nicorandil\u2010based FFR measurement. Diagnostic accuracy was assessed with patient\u2010level cluster bootstrap CIs across post hoc FFR and RFR strata. Threshold correspondence used ordinary least squares and Deming regression. Univariable logistic regression evaluated correlates of discordance (exploratory).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall threshold\u2010based agreement was 85.0% (95% CI 81.1%\u221288.5%; \u03ba\u2009=\u20090.684) with AUC 0.932 (95% CI 0.906\u22120.954). RFR exceeded FFR by +0.067 (patient\u2010mean limits of agreement \u22120.040 to +0.173). Agreement was 91.6\u221292.8% away from the FFR 0.80 decision boundary but 72.0\u221273.5% in the two flanking strata. RFR 0.89 corresponded to an FFR of approximately 0.823, similar with Deming regression. Agreement exceeded 92% outside RFR 0.87\u22120.91 but was 63.2% within this exploratory band and 68.8% within the 0.86\u22120.92 interval of previous hybrid strategies. LAD territory was an exploratory univariable correlate of discordance, which likely reflected the FFR distribution of LAD lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RFR showed high agreement with nicorandil\u2010based FFR, consistent with prior cohorts. Disagreement was concentrated near the FFR decision boundary, as expected for two correlated continuous indices dichotomized at fixed thresholds, and this study quantifies its frequency. Agreement was lowest near the RFR cut\u2010off (0.87\u20100.91), an exploratory interval that overlaps with previous hybrid gray zones and requires validation in outcome studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70933","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:24:01Z","timestamp":1790742241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Agreement and Threshold Correspondence Between Resting Full\u2010Cycle Ratio and Nicorandil\u2010Based Fractional Flow Reserve in Intermediate Coronary Stenosis: A Prospective Single\u2010Center Registry"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7657-8640","authenticated-orcid":false,"given":"Yonghoon","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3833-3789","authenticated-orcid":false,"given":"Onyou","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Won","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8299-1877","authenticated-orcid":false,"given":"Jung\u2010Joon","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-8464","authenticated-orcid":false,"given":"Hyung Joon","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8434-0157","authenticated-orcid":false,"given":"Jae Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Jun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-4562","authenticated-orcid":false,"given":"Cheol Woong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/204748739900600202","article-title":"International Trends in Coronary Heart Disease Mortality and Incidence Rates","volume":"6","author":"Beaglehole R.","year":"1999","journal-title":"European Journal of Cardiovascular Risk"},{"issue":"1","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12872-018-0761-0","article-title":"Burden of Ischaemic Heart Disease and Attributable Risk Factors in China From 1990 to 2015","volume":"18","author":"Zhang G.","year":"2018","journal-title":"BMC Cardiovascular Disorders"},{"issue":"16","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.4244\/EIJ-D-21-00192","article-title":"Temporal Trends in Clinical Outcomes After Percutaneous Coronary Intervention","volume":"17","author":"Asano T.","year":"2022","journal-title":"EuroIntervention"},{"issue":"2","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s10439-015-1399-z","article-title":"Coronary Stents: The Impact of Technological Advances on Clinical Outcomes","volume":"44","author":"Mennuni M. 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