{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:55:07Z","timestamp":1791903307804,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cangrelor reduces thrombotic events in patients undergoing percutaneous coronary intervention (PCI), with the advantage of rapid onset and offset. However, premature discontinuation may increase the risk of acute thrombosis for patients undergoing complex\/high\u2010risk PCI (CHIP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We evaluated the real\u2010world administration of cangrelor and related health outcomes for CHIP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A US retrospective physician panel medical chart review (1\/1\/2020 to 6\/26\/2025) included patients 18+ years old who received cangrelor (1st dose\u2009=\u2009index date) during CHIP. We summarized patients' characteristics in the 6 months pre\u2010index (baseline), cangrelor dosing and administration (IV bolus and\/or infusion), and clinical outcomes within 48\u2009h. We described MACE occurrence by dosing adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009200) were mostly male (85.5%), had a mean age of 63 years, and had a BMI of 30.2\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Most (87.5%) received a cangrelor bolus (30.0\u2009\u00b5g\/kg) and maintenance infusion (4.0\u2009\u00b5g\/kg\/mins), aligned with intended use recommendations. Of patients analyzed for infusion duration (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009134), 64.9% deviated from the recommendation of at least 2\u2009h or PCI length. Forty (29.9%) received cangrelor for less than the recommended duration. Overall, 30 (15%) patients experienced MACE, with a higher proportion of MACE seen in those who deviated from the recommended duration (16.1% [95% CI: 3.5%\u201323.1%] vs. 10.6% [95% CI: 9.1%\u201325.5%]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study provides real\u2010world insight into cangrelor use and clinical outcomes in CHIP patients, highlighting notable variability in infusion duration and differences in MACE occurrence by dosing adherence. Further comparative effectiveness studies are warranted to examine the potential impact of deviation from intended dose\/duration on clinical outcomes in CHIP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70942","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:42:33Z","timestamp":1791902553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cangrelor Dosing, Administration, and Clinical Outcomes for Patients Undergoing Complex and High\u2010Risk Percutaneous Coronary Interventions"],"prefix":"10.1002","author":[{"given":"Siyu","family":"Ma","sequence":"first","affiliation":[{"name":"Chiesi USA, Inc Cary North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-2496","authenticated-orcid":false,"given":"Wendy Y.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Berkeley Research Group, LLC Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Liang","sequence":"additional","affiliation":[{"name":"Berkeley Research Group, LLC Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Bryar","sequence":"additional","affiliation":[{"name":"Berkeley Research Group, LLC New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwyneth","family":"Wei","sequence":"additional","affiliation":[{"name":"Berkeley Research Group, LLC New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-5751","authenticated-orcid":false,"given":"Joshua D.","family":"Niznik","sequence":"additional","affiliation":[{"name":"Chiesi USA, Inc Cary North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5557-8633","authenticated-orcid":false,"given":"Christina","family":"Yin","sequence":"additional","affiliation":[{"name":"Chiesi USA, Inc Cary North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Liu\u2010Yi","sequence":"additional","affiliation":[{"name":"Chiesi USA, Inc Cary North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-5087","authenticated-orcid":false,"given":"Jimmy L.","family":"Kerrigan","sequence":"additional","affiliation":[{"name":"Ascension St. Thomas Heart Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Percutaneous Coronary Intervention","author":"Ahmad M.","year":"2021"},{"key":"e_1_2_11_3_1","unstructured":"\u201cOver 965 000 Angioplasties Are Performed Each Year in the United States \u201d iData Research Published August 29 2018 https:\/\/idataresearch.com\/over-965000-angioplasties-are-performed-each-year-in-the-united-states\/."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001412"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.12.019"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30366"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"E253","article-title":"A Novel Risk Score to Predict One\u2010Year Mortality in Patients Undergoing Complex High\u2010Risk Indicated Percutaneous Coronary Intervention (CHIP\u2010PCI)","volume":"33","author":"Sj B.","year":"2021","journal-title":"Journal of Invasive Cardiology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30749"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2985435"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.63956"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9934535"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001038"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd10040163"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvaf042"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.01.021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv547"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_2_11_19_1","unstructured":"\u201cKENGREAL (Cangrelor) [Prescribing Information] \u201d Chiesi USA Inc. 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