{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:40:36Z","timestamp":1792654836030,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23hk0102095"],"award-info":[{"award-number":["JP23hk0102095"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016242","name":"Boston Scientific Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real\u2010world data after percutaneous coronary intervention (PCI) using drug\u2010coated balloons (DCBs) in acute coronary syndrome (ACS) are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We compared 1\u2010year clinical outcomes after PCI with paclitaxel DCBs between the ACS and non\u2010ACS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ALLIANCE is a prospective, multicenter registry of PCI using paclitaxel DCBs. Primary endpoint was target lesion failure (TLF), defined as a composite of cardiac death, myocardial infarction (MI), or clinically driven target lesion revascularization. Secondary endpoints included all\u2010cause mortality at 1 year. Adverse events were adjudicated by an independent committee. Propensity score matching was performed to adjust for baseline differences between the ACS and non\u2010ACS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From July 2023 to February 2024, 1794 patients with de novo lesions (ACS 513 [28.6%] and non\u2010ACS 1281 [71.4%]) were enrolled at 57 medical institutions in Japan. Mean age was 71 years, and 76% were male. Among ACS patients, 34.7% had ST\u2010segment elevation MI, 33.9% non\u2013ST\u2010segment elevation MI, and 31.4% unstable angina. Intracoronary imaging was used in 88.5% of lesions. Bailout stenting after DCB angioplasty was required in only 1.1% of 1984 lesions. Technical success, defined as post\u2010procedural residual stenosis\u2009&lt;\u200940% and absence of flow\u2010limiting coronary dissection, was significantly lower in patients with ACS than those with non\u2010ACS. At 1 year, TLF occurred in 7.0% of ACS and 3.8% of non\u2010ACS patients (adjusted HR 1.83; 95% CI 1.06\u20133.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). All\u2010cause mortality was 6.4% and 3.3%, respectively (adjusted HR 2.06; 95% CI 1.13\u20133.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One\u2010year TLF and all\u2010cause mortality were significantly higher in ACS than non\u2010ACS patients treated with paclitaxel DCBs in real\u2010world clinical settings.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Registration:<\/jats:bold>\n                      Japan Registry of Clinical Trials (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/jrct.mhlw.go.jp\">https:\/\/jrct.mhlw.go.jp<\/jats:ext-link>\n                      ); unique identifier: jRCT1032230218.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70952","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:11:42Z","timestamp":1792653102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Year Clinical Outcomes of Paclitaxel\u2010Coated Balloon Angioplasty in Patients With and Without Acute Coronary Syndrome: The ALLIANCE Registry"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-2489","authenticated-orcid":false,"given":"Takashi","family":"Muramatsu","sequence":"first","affiliation":[{"name":"Department of Cardiology Fujita Health University Hospital Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-5489","authenticated-orcid":false,"given":"Kengo","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo 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General Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Morishige","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Matsuyama Red Cross Hospital Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokushima Red Cross Hospital Komatsushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Toho University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-5973","authenticated-orcid":false,"given":"Ken","family":"Kozuma","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Teikyo University Hospital Tokyo 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