{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:02:35Z","timestamp":1789642955682,"version":"4.0.0"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>\n                    We report a case of Noonan syndrome with loose anagen hair (\n                    <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">LAH<\/jats:styled-content>\n                    ), a rare variant of Noonan syndrome, with associated trichorrhexis nodosa and trichoptilosis. The\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">SHOC<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    mutation may be responsible for these additional hair shaft defects, revealing the importance of microscopic examination of hairs in these patients.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.1011","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T04:53:21Z","timestamp":1496292801000},"page":"1152-1154","source":"Crossref","is-referenced-by-count":5,"title":["Noonan syndrome with loose anagen hair associated with trichorrhexis nodosa and trichoptilosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Jennifer","family":"Kane","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School 281 Lincoln Street Worcester 01605 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Berrebi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School 281 Lincoln Street Worcester 01605 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School 281 Lincoln Street Worcester 01605 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Petkiewicz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School 281 Lincoln Street Worcester 01605 Massachusetts"},{"name":"Department of Pathology University of Massachusetts Medical School 55 Lake Avenue North Worcester 01655 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Massachusetts Medical School 55 Lake Avenue North Worcester 01605 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelena","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Massachusetts Medical School 55 Lake Avenue North Worcester 01605 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-6503","authenticated-orcid":false,"given":"Karen","family":"Wiss","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School 281 Lincoln Street Worcester 01605 Massachusetts"},{"name":"Department of Pediatrics University of Massachusetts Medical School 55 Lake Avenue North Worcester 01605 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1002\/ajmg.a.36098","article-title":"Expanding the SHOC2 mutation associated phenotype of Noonan syndrome with loose anagen hair: structural brain anomalies and myelofibrosis","volume":"161","author":"Gripp K. W.","year":"2013","journal-title":"Am. J. Med. Genet."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.425"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141019361"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.77513"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.06.007"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.1011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.1011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T06:32:17Z","timestamp":1764484337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.1011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/ccr3.1011"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.1011","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}