{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T06:35:48Z","timestamp":1764484548100,"version":"3.46.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>\n                    Studies have shown that difference in mt\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    mutation load among tissues is a result of postnatal modification. We present five family members with the m.8344A&gt;G with variable phenotypes but uniform intrapersonal distribution of mutation load, indicating that there is no postnatal modification of mt\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    mutation load in this genotype.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.1096","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T02:02:49Z","timestamp":1509674569000},"page":"2034-2039","source":"Crossref","is-referenced-by-count":2,"title":["Mitochondrial\n                    <scp>DNA<\/scp>\n                    mutation load in a family with the m.8344A&gt;G point mutation and lipomas: a case study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7203-9017","authenticated-orcid":false,"given":"Tina Dysgaard","family":"Jeppesen","sequence":"first","affiliation":[{"name":"Copenhagen Neuromuscular Clinic Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Al\u2010Hashimi","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Clinic Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Duno","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Wibrand","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grete","family":"Andersen","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Clinic Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Vissing","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Clinic Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.12.1701"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.039339"},{"key":"e_1_2_9_4_1","first-page":"35","volume-title":"Mitochondrial medicine","author":"Hirano M.","year":"2006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-002-0604-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8086-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91090-H"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290519"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170815"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.4.1012"},{"key":"e_1_2_9_11_1","first-page":"551","article-title":"Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A\u2013>G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged\u2010red fibers\u00a0(MERRF) syndrome","volume":"52","author":"Holme E.","year":"1993","journal-title":"Am. 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