{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:01:13Z","timestamp":1771236073215,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>\n                    Drug\u2010induced\n                    <jats:styled-content style=\"fixed-case\">aHUS<\/jats:styled-content>\n                    is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro\u2010inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemcitabine should be considered in the appropriate settings.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.1214","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T21:52:53Z","timestamp":1507585973000},"page":"1926-1930","source":"Crossref","is-referenced-by-count":36,"title":["Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life\u2010saving treatment"],"prefix":"10.1002","volume":"5","author":[{"given":"Rahul","family":"Gosain","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology James Graham Brown Cancer Center University of Louisville School of Medicine Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitoj","family":"Gill","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology James Graham Brown Cancer Center University of Louisville School of Medicine Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5100-578X","authenticated-orcid":false,"given":"Jacob","family":"Fuqua","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Louisville School of Medicine Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley H.","family":"Volz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy James Graham Brown Cancer Center University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika R.","family":"Kessans Knable","sequence":"additional","affiliation":[{"name":"Department of Pharmacy James Graham Brown Cancer Center University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Bycroft","sequence":"additional","affiliation":[{"name":"Department of Pharmacy James Graham Brown Cancer Center University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Seger","sequence":"additional","affiliation":[{"name":"Department of Pharmacy James Graham Brown Cancer Center University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Gosain","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Roswell Park Cancer Institute Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.","family":"Rios","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology The Mark H. Zangmeister Cancer Center Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Hsien","family":"Chao","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Texas Transplant Physician Group \u2010 Methodist Physicians San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001581"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902814"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-60"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-611335"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060003831.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470015535"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00873232"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9%3C2023::AID-CNCR21%3E3.0.CO;2-2","article-title":"A review of hemolytic uremic syndrome in patient targeted with gemcitabine therapy","volume":"85","author":"Fung M. C.","year":"1999","journal-title":"Cancer"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2004.11.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfv059"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0280-x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02210310"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208981"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-516237"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl507"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2010.07.020"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.1214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.1214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T06:31:56Z","timestamp":1764484316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.1214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,9]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/ccr3.1214"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.1214","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,9]]}}}