{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T15:28:56Z","timestamp":1766503736071,"version":"3.46.0"},"reference-count":6,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>\n                    Pyoderma gangrenosum (\n                    <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\n                    ) is a morbid necrotizing neutrophilic dermatoses for which current treatments are inadequate. Here, we describe the use of a novel noncytotoxic regimen of the deoxycytidine analog decitabine to treat underlying myeloid malignancy causing\n                    <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\n                    , to thereby produce safe and effective resolution of extensive\n                    <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/ccr3.1221","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:08:42Z","timestamp":1509494922000},"page":"2025-2027","source":"Crossref","is-referenced-by-count":10,"title":["Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-8405","authenticated-orcid":false,"given":"Mostafa F. M.","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Taussig Cancer Institute Cleveland Clinic Cleveland Ohio"},{"name":"Internal Medicine Department Assiut University Hospitals Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9757-1031","authenticated-orcid":false,"given":"Yogen","family":"Saunthararajah","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Taussig Cancer Institute Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13493"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.130"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2958"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78789"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1738"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.802315"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.1221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.1221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T06:32:26Z","timestamp":1764484346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.1221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":6,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/ccr3.1221"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.1221","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2017,10,31]]}}}