{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:31:52Z","timestamp":1783071112410,"version":"3.54.6"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:p>Methotrexate (<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>)\u2010induced encephalopathy is a grave complication in patients with malignancies. The early diagnosis of acute encephalopathy was difficult by conventional computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>), and T1\u2010 or T2\u2010weighted magnet resonance (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) imaging. We report that the diffusion\u2010weighted (<jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>) imaging is useful for early detection of acute leukoencephalopathy.<\/jats:p>","DOI":"10.1002\/ccr3.1376","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:13:07Z","timestamp":1516633987000},"page":"469-472","source":"Crossref","is-referenced-by-count":7,"title":["Diffusion\u2010weighted imaging characteristics of methotrexate\u2010induced acute encephalopathy"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0072-7974","authenticated-orcid":false,"given":"Mayumi","family":"Yoshimi","sequence":"first","affiliation":[{"name":"Department of Hematology &amp; Blood Transfusion Mitsui Memorial Hospital Chiyoda\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Radiology Mitsui Memorial Hospital Chiyoda\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108093450606"},{"key":"e_1_2_7_3_1","first-page":"1887","article-title":"Neurotoxicity of intrathecal methotrexate: MR imaging findings","volume":"24","author":"Sandoval C.","year":"2003","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"e_1_2_7_4_1","first-page":"1688","article-title":"Acute methotrexate neurotoxicity: findings on diffusion\u2010weighted imaging and correlation with clinical outcome","volume":"25","author":"Rollins N.","year":"2004","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-005-4569-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197801)41:1<36::AID-CNCR2820410108>3.0.CO;2-I"},{"key":"e_1_2_7_7_1","first-page":"249","article-title":"Toxic leukoencephalopathy","volume":"22","author":"Filley C. M.","year":"1999","journal-title":"Clin. Neuropharmacol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-010-0931-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.5.1712"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921001)70:7<1997::AID-CNCR2820700732>3.0.CO;2-G"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.6910"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401098"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1986.4.12.1845"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850915)56:6<1356::AID-CNCR2820560623>3.0.CO;2-H"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm466"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.04.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.4.252"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90464-6"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.1376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.1376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:01:57Z","timestamp":1695542517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.1376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/ccr3.1376"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.1376","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]}}}