{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:51:50Z","timestamp":1771469510928,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>Methylmalonic aciduria children must follow an adequate diet with low protein intake and should be regularly monitored to prevent complications. Although skin lesions like acrodermatitis enteropathica are rare in this disease, their appearance should be correlated with possible low plasma isoleucine level and it can be a sign of decompensation.<\/jats:p>","DOI":"10.1002\/ccr3.1509","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T18:43:47Z","timestamp":1523731427000},"page":"1048-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acrodermatitis dysmetabolica as a sign of methylmalonic aciduria decompensation"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-0695","authenticated-orcid":false,"given":"Joana","family":"Rosa","sequence":"first","affiliation":[{"name":"Pediatric Department Hospital of Divino Espirito Santo of Ponta Delgada, EPER S\u00e3o Miguel Island, Azores Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Beatriz","family":"Fraga","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital of Divino Espirito Santo of Ponta Delgada, EPER S\u00e3o Miguel Island, Azores Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department Hospital of Divino Espirito Santo of Ponta Delgada, EPER S\u00e3o Miguel Island, Azores Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00facia","family":"Maia","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital of Divino Espirito Santo of Ponta Delgada, EPER S\u00e3o Miguel Island, Azores Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lu\u00edsa","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital of Divino Espirito Santo of Ponta Delgada, EPER S\u00e3o Miguel Island, Azores Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda","family":"Gomes","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital of Divino Espirito Santo of Ponta Delgada, EPER S\u00e3o Miguel Island, Azores Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000422"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0130-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12876"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70364-7"},{"key":"e_1_2_8_6_1","first-page":"30","article-title":"Consensus for the nutritional treatment of isovaleric, propionic and methylmalonic acidurias","volume":"39","author":"Rocha J.","year":"2008","journal-title":"Acta. Pediatr. Port."},{"key":"e_1_2_8_7_1","first-page":"741","article-title":"Skin\u00a0manifestation of\u00a0methylmalonic acidemia: case report and review of the literature","volume":"150","author":"Karamifar H.","year":"2015","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"e_1_2_8_8_1","first-page":"122","article-title":"Acrodermatitis Acidemica associated with deficiency of branched chain amino acids in maple syrup urine disease","volume":"27","author":"Chen C. Y.","year":"2009","journal-title":"Dermatol. Sinica"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890480083012"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.1509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.1509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T04:00:52Z","timestamp":1764475252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.1509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,14]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/ccr3.1509"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.1509","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,14]]},"assertion":[{"value":"2017-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}