{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:19:55Z","timestamp":1766391595120,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:p>Hemophagocytic lymphohistiocytosis (HLH) is a life\u2010threatening hyper activation of the immune system. Rare cases associated with HELLP syndrome and other similar conditions in pregnancy have been reported. Despite the improved survival rates with etoposide and dexamethasone\u2010based regimens, HLH remains a challenging disease. Experience in pregnant patients is exceedingly rare.<\/jats:p>","DOI":"10.1002\/ccr3.1828","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T02:17:03Z","timestamp":1541470623000},"page":"2466-2470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hemophagocytic lymphohistiocytosis in the setting of HELLP Syndrome"],"prefix":"10.1002","volume":"6","author":[{"given":"Sarmen","family":"Sarkissian","sequence":"first","affiliation":[{"name":"Pacific Shoes Medical Group Long Beach California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasir","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of California, Irvine Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, Irvine Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Constable","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine University of California, Irvine Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-9841","authenticated-orcid":false,"given":"Elizabeth","family":"Brem","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of California, Irvine Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.10.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199611000-00002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2350-y"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-356261"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2008.23.3.439"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3164"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.54"},{"key":"e_1_2_6_11_1","article-title":"Acute fatty liver and HELLP syndrome: two distinct pregnancy disorders","volume":"73","author":"Virgin\u2010Degarcia P","year":"2001","journal-title":"Int J Gynaecol Obstet"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-219516"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2016.135"},{"key":"e_1_2_6_14_1","first-page":"2529","article-title":"Soluble interleukin\u20102 receptor is a sensitive diagnostic test in adult HLH. Blood","volume":"1","author":"Anna Hayden ML","year":"2017","journal-title":"Advances"},{"key":"e_1_2_6_15_1","first-page":"216","article-title":"Epstein\u2010Barr virus\u2010associated hemophagocytic lymphohistiocytosis during pregnancy","volume":"58","author":"Ikeda M","year":"2017","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_6_16_1","first-page":"65","article-title":"Unique triad of 'pregnancy, kala azar and hemophagocytic lymphohistiocytic syndrome from a non\u2010endemic region'","volume":"63","author":"Pawar S","year":"2015","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2015.6100"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2014.11.023"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1366154"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00834-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000157757.54948.9b"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2007.n.033"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0277-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2009.02.016"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(09)70043-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4314\/wajm.v30i1.69922","article-title":"Human immunodeficiency virus associated with haemophagocytic syndrome in pregnancy: a case report","volume":"30","author":"Arewa OP","year":"2011","journal-title":"West Afr J Med"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412Y.0000000007"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-011-0073-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000385"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.1828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.1828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.1828","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.1828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:16:57Z","timestamp":1694744217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.1828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/ccr3.1828"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.1828","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2018,11,5]]},"assertion":[{"value":"2018-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}