{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T04:46:02Z","timestamp":1764477962767,"version":"3.46.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>We describe a rare case of Graves\u2019 disease presenting with atrial fibrillation and severe cholestasis. An extensive evaluation for hepatobiliary causes of cholestasis, including hepatic biopsy, was entirely negative. He was successfully treated with methimazole and eventual thyroidectomy. With caution, thionamides can be utilized successfully for such patients.<\/jats:p>","DOI":"10.1002\/ccr3.1859","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T05:17:08Z","timestamp":1539321428000},"page":"2240-2245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Severe cholestatic jaundice associated with Graves\u2019 disease"],"prefix":"10.1002","volume":"6","author":[{"given":"Abebe","family":"Abebe","sequence":"first","affiliation":[{"name":"Division of General and Geriatric Medicine, Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh M.","family":"Eck","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Genetics, Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Holyoak","sequence":"additional","affiliation":[{"name":"Division of General and Geriatric Medicine, Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510030"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329903600521"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"1727","article-title":"Fifty years of experience with propylthiouracil\u2010associated hepatotoxicity: what have we learned?","volume":"82","author":"Williams KV","year":"1997","journal-title":"J Clin Endocrin Metab"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"334","article-title":"Autoimmune cholangiopathy and high\u2010output heart failure in a patient with graves disease","volume":"7","author":"Venkat D","year":"2011","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"5","key":"e_1_2_8_6_1","first-page":"337","article-title":"Hepatic dysfunction in hyperthyroidism","volume":"7","author":"Khemichian S","year":"2011","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20085"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02045"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199912000-00004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.06.030"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042972"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161222.OR"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.13.5.476"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39247.452141.BE"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2016-1065"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.1859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.1859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T04:44:42Z","timestamp":1764477882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.1859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,12]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/ccr3.1859"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.1859","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2018,10,12]]},"assertion":[{"value":"2018-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}