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The purpose of this case series study was to report our experience with Integra\u00ae bilayer wound matrix for reconstruction of intraoral oncologic defects. Case records of 6 patients with intraoral oncologic defects reconstructed with Integra\u00ae bilayer wound matrix were retrospectively reviewed. The surgical defect location, size, and time to removal of surgical splint varied. Clinically, normal oral epithelialization was noted for all patients. One patient demonstrated a small area of dehiscence and bone exposure after adjuvant radiation therapy which resolved with minimal intervention. Integra bilayer wound matrix is a viable and versatile option for reconstruction of intraoral oncologic surgical defects. Further exploration of wound healing with Integra\u00ae matrix, surgical techniques, and cost\u2010effectiveness is advocated.<\/jats:p>","DOI":"10.1002\/ccr3.3501","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T09:33:01Z","timestamp":1605173581000},"page":"213-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reconstruction of intraoral oncologic surgical defects with Integra<sup>\u00ae<\/sup> bilayer wound matrix"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-6535","authenticated-orcid":false,"given":"Akanksha","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry and Prosthodontics The University of Texas School of Dentistry  Houston TX 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