{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:44:00Z","timestamp":1788781440312,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 5\u2010year\u2010old Doberman Pinscher dog was presented with sudden onset left\u2010sided periocular bleeding following third eyelid gland replacement surgery. Left\u2010sided exophthalmos and 360\u2010degrees subconjunctival hemorrhage were present. The ophthalmic examination revealed blindness with absent direct and consensual pupillary light reflexes. A superficial exposure ulcerative keratitis due to exophthalmos was also present. Computed tomography (CT) revealed a large left\u2010sided retrobulbar mass lesion surrounding the optic nerve, compatible with a retrobulbar hematoma. Due to absence of orbital fractures and no history of trauma, a coagulopathy was strongly suspected. The buccal mucosal bleeding time (BMBT) was prolonged (&gt;4\u00a0minutes) consistent with a primary hemostatic defect in the absence of thrombocytopenia. Von Willebrand factor antigens levels were decreased (24%\u2010 Normal Range: 50%\u2010150%). Surgical drainage of the retrobulbar hematoma was performed uneventfully thirty minutes after subcutaneous injection of desmopressine acetate, Minirin\u00ae (1\u00a0\u00b5g\/kg, SC). Von Willebrand disease type I gene mutation was confirmed by PCR amplification of the DNA encoding von Willebrand factor. This case report demonstrates that hemostatic disorders, including von Willebrand Disease (vWD), are a risk factor for orbital bleeding following surgical trauma. Retrobulbar hematoma should be considered as a differential diagnosis in any dog with exophthalmos.<\/jats:p>","DOI":"10.1002\/ccr3.3735","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T19:01:49Z","timestamp":1611082909000},"page":"1235-1240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Case report of unilateral retrobulbar hematoma associated with von Willebrand disease in a Doberman Pinscher dog"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-4365","authenticated-orcid":false,"given":"Jean\u2010Baptiste","family":"Barbry","sequence":"first","affiliation":[{"name":"Lorrainevet Ludres France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-4458","authenticated-orcid":false,"given":"Anne\u2010Sophie","family":"Poinsard","sequence":"additional","affiliation":[{"name":"Lorrainevet Ludres France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Bouzouraa","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Clinique V\u00e9t\u00e9rinaire Armonia Villefontaine France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexane","family":"Durand","sequence":"additional","affiliation":[{"name":"Division of Clinical Radiology Department of Clinical Veterinary Medicine Vetsuisse\u2010Faculty University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-9018","authenticated-orcid":false,"given":"Olivier","family":"Balland","sequence":"additional","affiliation":[{"name":"Lorrainevet Ludres France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"2126","volume-title":"Textbook of Veterinary Internal Medicine","author":"Callan MB","year":"2017"},{"key":"e_1_2_13_3_1","first-page":"793","volume-title":"Veterinary ophthalmology","author":"Spiess BM","year":"2013"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12486"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1110-8"},{"key":"e_1_2_13_6_1","first-page":"1","article-title":"Unilateral subconjunctival and retrobulbar hemorrhage secondary to bradifacoum toxicity in a dog","author":"Kuhn SE","year":"2013","journal-title":"Case Rep Vet Med"},{"key":"e_1_2_13_7_1","first-page":"E81","article-title":"A case of retrobulbar hematoma due to Von Willebrand disease in a dog. Abstract: annual Scientific Meeting of the European Society of Veterinary Ophthalmologists, Dublin, Ireland, 2019","volume":"22","author":"Amorin AM","year":"2019","journal-title":"Vet Ophthalmol"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.04.005"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2017.10.025"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2018-207937"},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.55460\/1CLD-XJUV","article-title":"Emergency lateral canthotomy and cantholysis: a simple procedure to preserve vision from sight threatening orbital hemorrhage","volume":"9","author":"Ballard SR","year":"2009","journal-title":"J Spec Oper Med"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2015.07.010"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2011.00702.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.861"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40575-019-0073-4"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00296.x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.05.027"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-004-0999-3"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20161031-09"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175940"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.3735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.3735","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.3735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T03:48:50Z","timestamp":1693626530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.3735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/ccr3.3735"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.3735","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,19]]},"assertion":[{"value":"2020-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}