{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:36:51Z","timestamp":1774669011777,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a distinct part of severe cutaneous adverse reactions (SCARs). It is characterized by fever, rash, hematologic abnormalities, lymphadenopathy, or\/and different degrees of visceral organ involvement. Its diagnosis is particularly challenging due to the variability of its clinical presentations and its long latency period (2\u20136\u00a0weeks). Allopurinol, an uric acid\u2010lowering drug, has been incriminated in several cases of allopurinol\u2010induced DRESS syndrome. Through this paper, we present a case of allopurinol\u2010induced DRESS syndrome with initial oral mucosal involvement. A 69\u2010year\u2010old female patient presented with an erosive cheilitis that started 1\u00a0week prior to his presentation. The cheilitis was associated with maculopapular rash and fever. She started taking allopurinol, as treatment of Gout, 6\u00a0weeks before hospitalization. The histologic findings obtained from skin biopsy were consistent with a toxic drug reaction. A complete blood count (CBC) showed a moderate eosinophilia. Alteration of renal function was also noted, and the diagnosis of allopurinol\u2010induced DRESS syndrome was made. Systemic corticosteroid therapy was therefore started. The patient completely recovered and had been healthy for 3\u00a0years before developing a recurrence after re\u2010challenge with allopurinol.<\/jats:p>","DOI":"10.1002\/ccr3.5123","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T02:00:00Z","timestamp":1637632800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Erosive cheilitis as an early manifestation in DRESS syndrome"],"prefix":"10.1002","volume":"9","author":[{"given":"Wahbi","family":"Ben Salha","sequence":"first","affiliation":[{"name":"Department of Dental Medicine Dental Faculty of Monastir SAHLOUL Hospital (Sousse) University of Monastir Monastir Tunisia"},{"name":"Laboratory of Oral Health and Maxillofacial Rehabilitation (LR12ES11) University of Monastir Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-3537","authenticated-orcid":false,"given":"Eya","family":"Moussaoui","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Dental Faculty of Monastir SAHLOUL Hospital (Sousse) University of Monastir Monastir Tunisia"},{"name":"Laboratory of Oral Health and Maxillofacial Rehabilitation (LR12ES11) University of Monastir Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamia","family":"Oualha","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Dental Faculty of Monastir SAHLOUL Hospital (Sousse) University of Monastir Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihed","family":"Anoun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine of Sousse SAHLOUL Hospital (Sousse) Sousse 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