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The etiology of MD is currently unknown; previous studies have suggested both psychiatric and infectious causes, with increasing interest over the previous decade in elaborating a possible pathogenesis for the disease secondary to infection by Borrelia species. We report a middle\u2010aged Caucasian female who developed symptoms of MD in the days following exposure to a tick bite after spending an afternoon hiking through a wooded area. She was subsequently treated with a course of Doxycycline and found on two\u2010week follow\u2010up to have complete remission of her symptoms. This case report further supports the theory for an infectious etiology of MD and encourages future studies into its pathophysiology.<\/jats:p>","DOI":"10.1002\/ccr3.5148","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T14:58:05Z","timestamp":1638629885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of Morgellons disease with doxycycline"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-5871","authenticated-orcid":false,"given":"Jeff F.","family":"Zhang","sequence":"first","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerthy","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"SRM Medical College Hospital and Research Centre Kattankulathur Kanchipuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Molloy","sequence":"additional","affiliation":[{"name":"St. Vincent Health Center, Sisters of Charity Hospital Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11533150-000000000-00000"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2018.7660"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S152343"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029908"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S116608"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2018.08.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5175"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijpbs.9170"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.276"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207144.2011.546263"},{"key":"e_1_2_10_12_1","first-page":"167","article-title":"Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease","volume":"4","author":"Middelveen MJ","year":"2011","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_10_13_1","first-page":"1","article-title":"Characterization and evolution of dermal filaments from patients with Morgellons disease","volume":"6","author":"Middelveen MJ","year":"2013","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.2.440"},{"key":"e_1_2_10_15_1","first-page":"67","article-title":"Morgellons disease: analysis of a population with clinically confirmed microscopic subcutaneous fibers of unknown etiology","volume":"3","author":"Savely VR","year":"2010","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_10_16_1","unstructured":"Centers for Disease Control and Prevention.2021.Lyme disease treatment | CDC. 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