{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:48Z","timestamp":1753862868935,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Yokenella regensburgei<\/jats:italic> is a Gram\u2010negative, oxidase\u2010negative motile rod which is rarely isolated from human caused a few opportunistic infections in immunocompromised patients so far. We report the first case of otitis media combined with externa caused by <jats:italic>Y<\/jats:italic>.\u00a0<jats:italic>regensburgei<\/jats:italic> in an immunocompetent patient. A 56\u2010year\u2010old male patient visited the outpatient clinic of the Otolaryngology Department due to otorrhea of the right ear started after diving in mountain valley in Korea 3\u00a0days ago. He was immunocompetent adult and clinical examination revealed swelling and debris accumulation in the right external auditory canal with an intact, erythematous tympanic membrane, and clear, odorless otorrhea. Microbiological culture of otorrhea revealed <jats:italic>Y<\/jats:italic>.\u00a0<jats:italic>regensburgei<\/jats:italic> by matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight and PCR\u2010based 16S rRNA gene sequencing. His otorrhea persisted, and a pinpoint perforation occurred in the inferior anterior portion of the tympanic membrane. 50% acetic acid irrigation and 500\u00a0mg of oral ciprofloxacin were prescribed, and his infection was cured after 4\u00a0weeks. This is the first case of otitis media combined with externa caused by <jats:italic>Yokenella regensburgei<\/jats:italic> in an immunocompetent patient. Given that <jats:italic>Yokenella<\/jats:italic> species infections are rare, especially in immunocompetent patients, this case highlights the importance of history taking and communication between clinicians and laboratory physicians. Molecular identification methods assist in identifying rare pathogens.<\/jats:p>","DOI":"10.1002\/ccr3.5177","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T09:53:40Z","timestamp":1639389220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["First report of <i>Yokenella regensburgei<\/i> isolated from external auditory canal after diving in valley"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-2124","authenticated-orcid":false,"given":"Gina","family":"Na","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Inje University, Ilsan Paik Hospital Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-6905","authenticated-orcid":false,"given":"Je Eun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University, Ilsan Paik Hospital Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7928-7195","authenticated-orcid":false,"given":"Jeonghyun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Inje University, Ilsan Paik Hospital Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.7883\/yoken1952.37.117"},{"key":"e_1_2_10_3_1","first-page":"5962463","article-title":"Yokenella regensburgei septicemia in a chinese farmer immunosuppressed by HIV: A case report and literature review","volume":"2017","author":"Chi X","year":"2017","journal-title":"Case Rep Infect Dis"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1016\/j.jiac.2019.03.025"},{"key":"e_1_2_10_5_1","first-page":"137","article-title":"Infectious diarrhea with sepsis symptoms from Yokenella Regensburgei","volume":"5","author":"Milori AME","year":"2017","journal-title":"J Microbiol Experiment"},{"key":"e_1_2_10_6_1","first-page":"224","article-title":"Otitis externa","volume":"116","author":"Wiegand S","year":"2019","journal-title":"Dtsch Arztebl Int"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1177\/0194599813514365"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1007\/s15010-011-0139-z"},{"key":"e_1_2_10_9_1","first-page":"31","volume-title":"Brain Abscess Due to Yokenella Regensburgei in a Patient with Primary CNS Lymphoma (31)","author":"Rinonos SZ","year":"2020"},{"key":"e_1_2_10_10_1","first-page":"135","article-title":"First report of yokenella regensburgei isolated from the wound exudate after disarticulation due to diabetic foot infection in Korea","volume":"18","author":"Lee SM","year":"2015","journal-title":"Acm"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.5177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.5177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.5177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:55:07Z","timestamp":1693209307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.5177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/ccr3.5177"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.5177","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05177"}}