{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:29Z","timestamp":1753862909344,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by symmetric and destructive polyarthritis with a broad\u2010spectrum clinical manifestation of various organs. RND is an unusual distinctive manifestation of RA and typically develops in severe RA. This report aims to present an unusual and a rare neutrophilic skin condition, in a seronegative RA Sudanese patient. A 51\u2010year\u2010old woman was diagnosed with RA three years ago and a history of bilateral polyarthritis, presented with a skin rash involving her extremities and abdomen. Clinical examination of her skin revealed the presence of maculopapular lesions affecting the extensor surfaces of the lower extremities and the lower part of the abdomen with hyperpigmentation. Hand X\u2010ray demonstrated periarticular osteopenia, and laboratory and immunological studies that include C\u2010reactive protein, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anticitrullinated peptide antibodies (ACPAs), and antinuclear factor in addition to skin biopsy were all suggested a diagnosis of neutrophilic dermatosis. The patient received steroids for the skin lesion still no significant improvement was seen, and then, cyclosporin 100\u00a0mg was administrated twice\/ day with close monitoring, and two weeks later marked improvement was shown.<\/jats:p>","DOI":"10.1002\/ccr3.5249","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T04:40:07Z","timestamp":1641616807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report"],"prefix":"10.1002","volume":"10","author":[{"given":"Amel Awad","family":"IbnIdris Rodwan","sequence":"first","affiliation":[{"name":"Department of Rheumatology Sudan Medical Specialization Council Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel Gaffar.","family":"A. Mohammed","sequence":"additional","affiliation":[{"name":"Rheumatology Department Security Forces Hospital Makkah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1050-2771","authenticated-orcid":false,"given":"Mohammed Elmujtba","family":"Adam Essa","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Medical and Cancer Research Institute Nyala Sudan"},{"name":"Faculty of Medicine Al Fashir University Al Fashir Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atif Elhadi","family":"Abdalla Babker","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Gezira Wad Madani Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Mohamed Abdelsatir","sequence":"additional","affiliation":[{"name":"Department of Histopathology Khartoum Histocentre Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elnour","family":"Mohammed Elagib","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Omdurman Military Hospital Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.03.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_25_17"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.05.001"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"82402c","article-title":"A case of rheumatoid neutrophilic dermatosis","volume":"2","author":"Akdeniz N","year":"2008","journal-title":"J Turk Acad Dermatol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8632-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.07.008"},{"issue":"2","key":"e_1_2_10_9_1","first-page":"133","article-title":"Rheumatoid neutrophilic dermatitis","volume":"78","author":"Bevin AA","year":"2006","journal-title":"Cutis"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07682.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2018.1106"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"21","article-title":"Extra\u2010articular manifestations of rheumatoid arthritis","volume":"66","author":"Matsushita M","year":"2020","journal-title":"JMJ"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2019.90363"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-015-3594-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03708.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0092-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00401.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheumatol.2014.140032"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2016.06.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_161_19"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-5483-4_12"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01488.x"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.5249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.5249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.5249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T10:27:04Z","timestamp":1693218424000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.5249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/ccr3.5249"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.5249","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05249"}}