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Late\u2010onset neutropenia (LON) is a rarely reported complication of ocrelizumab therapy. We report a case of severe late\u2010onset neutropenia in a patient with primary progressive multiple sclerosis treated with ocrelizumab with neutropenia occurring 3\u00a0months after the last dose received treated with empirical broad\u2010spectrum intravenous antibiotics and filgrastim. Severe late\u2010onset neutropenia is a rare unpredictable adverse event and outlines the importance of regular routine blood workup for detecting severe neutropenia early in its course.<\/jats:p>","DOI":"10.1002\/ccr3.5299","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T03:18:44Z","timestamp":1642648724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Severe late\u2010onset neutropenia induced by ocrelizumab in a multiple sclerosis patient: A case report"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-1086","authenticated-orcid":false,"given":"Robin","family":"Rauniyar","sequence":"first","affiliation":[{"name":"Maharajgunj Medical Campus Tribhuvan University Institute of Medicine  Maharajgunj Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9568-1333","authenticated-orcid":false,"given":"Rahul","family":"Rauniyar","sequence":"additional","affiliation":[{"name":"Internal Medicine The Wright Center for Graduate Medical Education  Scranton Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-2288","authenticated-orcid":false,"given":"Ankita","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Nepal Army Institute of Health Sciences Tribhuvan University  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3717-4891","authenticated-orcid":false,"given":"Shikha","family":"Yadav","sequence":"additional","affiliation":[{"name":"Nepalgunj Medical College Kathmandu University  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-2531","authenticated-orcid":false,"given":"Sreekant","family":"Avula","sequence":"additional","affiliation":[{"name":"Internal Medicine The Wright Center for Graduate Medical Education  Scranton Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285615601933"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756286418773025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0488-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102155"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116603"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606468"},{"key":"e_1_2_9_8_1","unstructured":"OCREVUSTM (ocrelizumab) injection.pdf [Internet].https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/761053lbl.pdf. 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