{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:58Z","timestamp":1753862878977,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CRPS is a type of severe pain syndrome and can be triggered by previous surgery or trauma. CRPS involves vasomotor changes such as changes in color and temperature of the skin, edema, increased sensitivity to touch, and a limited range of movement. Depending on the presence of nerve damage, CRPS is divided into two types. CRPS type II is associated with a confirmed peripheral nerve injury, while CRPS type I is not associated with an apparent peripheral nerve injury. Despite the ongoing therapy, sometimes, patients still have persistent, burning pain. Intractable CRPS that fail more conservative treatments may undergo neuromodulation. We want to present to your attention a case report of the successful treatment of a patient with CRPS type II using epidural unilateral stimulation. The 44\u2010year\u2010old woman came to us with complaints of burning pain and numbness of 1\u20133 fingers of the right hand, the lateral surface of the right wrist, and lower quarter of the forearm, and shooting pain in the projection of the right median nerve from the shoulder to the wrist. A clinical diagnosis was made\u2014CRPS type II. During the stimulation trial, the most effective pain relief was obtained when the electrode was located in the right side of epidural space at the C4\u2010Th1 level. The implantation of a pulse generator was performed, and the final selection of the stimulation parameters was carried out (Pulse width: 60\u00a0ms, Rate: 210\u00a0Hz, and Amplitude: 0.9\u20131.6\u00a0V). The severity of pain syndrome was measured using validated scales in the preoperative period (VAS: 8\u20139, Pain Detect: 22, NTSS\u20109: 4.62, and DN4: 8), in the early postoperative period (VAS: 0\u20131, Pain Detect: 6, NTSS \u22129: 0.66, and DN4: 1), and after 12\u00a0months (VAS: 0\u20132, Pain Detect: 6, NTSS\u20109: 0.99, and DN4: 1). Observation during 12\u00a0months showed that a stable analgesic effect of neurostimulation was achieved using standard neuromodulation regimens and the adaptive stim option. Unilateral stimulation is an effective type of SCS in the treatment of pain syndromes. adaptive stim is usually not applicable for lead implantation at the cervical level. Nevertheless, the rational use of stimulation at threshold values allowed our patient to use adaptive stim in a non\u2010standard situation.<\/jats:p>","DOI":"10.1002\/ccr3.5305","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T05:27:04Z","timestamp":1642742824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidural unilateral stimulation with \u201cadaptive stim\u201d option in treatment of type II CRPS"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-801X","authenticated-orcid":false,"given":"Armen Samvelovich","family":"Simonyan","sequence":"first","affiliation":[{"name":"Neurosurgery Department Research Center of Neurology Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir Mikhaylovich","family":"Tyurnikov","sequence":"additional","affiliation":[{"name":"Neurosurgery Department Research Center of Neurology Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Dmitrievna","family":"Simonyan","sequence":"additional","affiliation":[{"name":"Neurology Department Burnasyan FMBC Research Center of FMBA of Russia Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artem Olegovich","family":"Gushcha","sequence":"additional","affiliation":[{"name":"Neurosurgery Department Research Center of Neurology Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2020-0120"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13295"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-016-0066-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002146"},{"key":"e_1_2_10_6_1","first-page":"137808","article-title":"Complex regional pain syndrome: an evolving perspective","volume":"12","author":"Cutts S","year":"2020","journal-title":"Postgrad Med J"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200006000-00010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000192515.50955.9f"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000233257.76957.b2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008313430904"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13144"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-019-04166-y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000814"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_47_20"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2019-0081"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.5305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.5305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.5305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T10:24:51Z","timestamp":1693218291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.5305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/ccr3.5305"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.5305","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05305"}}