{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:40:01Z","timestamp":1793400001236,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Toxic Epidermal Necrolysis\/Steven\u2013Johnson Syndrome (TEN\/SJS) is one of the most serious dermatological adverse reactions triggered mainly by drugs and less likely by infections. COVID\u201019 disease is caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS\u2010CoV\u20102) with a wide range of clinical manifestations. Skin involvement is common in COVID\u201019 patients including urticaria, purpura, and vasculitis. There were reported cases of TEN\/SJS in adults with COVID\u201019 infections and only two reported cases in pediatric patients. The causality relationship between COVID\u201019 infection and TEN\/SJS was not established in most cases due to history of drug usage that could be the trigger. In this study, we are reporting a case of previously healthy child apart from COVID\u201019 infection who was admitted to the intensive care unit with TEN involving more than 30% of body surface area confirmed by skin biopsy. The child was treated with intravenous immunoglobulins, steroids, and cyclosporin with a very good outcome.<\/jats:p>","DOI":"10.1002\/ccr3.5565","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T03:33:08Z","timestamp":1647228788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Toxic Epidermal Necrolysis associated with COVID\u201019 infection: A case report"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3213-126X","authenticated-orcid":false,"given":"Lamia","family":"Jouhar","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marva","family":"Yahya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohair","family":"Elsiddiq","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,13]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"e50","article-title":"Clinical characteristics of COVID\u201019 infection in newborns and pediatrics: a systematic review","volume":"8","author":"Panahi L","year":"2020","journal-title":"Arch Acad Emerg Med"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15414"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2019.0977"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303718"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-020-00133-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16887"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4249"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14574"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13467"},{"key":"e_1_2_10_11_1","article-title":"COVID\u201019 presenting like Steven Johnson Syndrome in a pediatric patient","author":"Parlakay AO","year":"2020","journal-title":"Authorea Preprints"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.5565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.5565","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.5565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:47:12Z","timestamp":1692953232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.5565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/ccr3.5565"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.5565","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"2021-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05565"}}