{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:29:33Z","timestamp":1776205773543,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Extracorporeal membrane oxygenation (ECMO) is a life\u2010saving rescue therapy used in acute respiratory failure refractory to invasive mechanical ventilation. Recent studies on positive outcomes of extended ECMO therapy are promising. We describe a case of a 2\u2010year 8\u2010month\u2010old female child with necrotizing pneumonia secondary to\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Influenza A<\/jats:italic>\n                    , and\n                    <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                    , who survived with intact neurological function and no long\u2010term adverse outcomes after a prolonged ECMO run of 86\u2009days. To the best of our knowledge, this is one of the longer durations of ECMO with transplant\u2010free survival in a pediatric patient requiring respiratory support with good recovery and a good functional outcome. Allowing time for native lung recovery is pivotal for optimal recovery, despite significant lung injury due to the underlying disease process. With evolving ECMO experience, clinicians may need to re\u2010consider the conventional maximum duration of ECMO in children with severe respiratory failure on a case\u2010by\u2010case basis.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.5973","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T05:29:17Z","timestamp":1657517357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Necrotizing pneumonia requiring prolonged extracorporeal membrane oxygenation: Pushing the boundaries in pediatric\n                    <scp>ECMO<\/scp>"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-6188","authenticated-orcid":false,"given":"Pravin","family":"R. R.","sequence":"first","affiliation":[{"name":"General Pediatrics KK Women's &amp; Children's Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-7441","authenticated-orcid":false,"given":"Suresh","family":"Chandran","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Neonatology KK Women's &amp; Children's Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School National University of Singapore  Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7679-3842","authenticated-orcid":false,"given":"Yi Hua","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010NUS Medical School National University of Singapore  Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"},{"name":"Pediatric Respiratory Medicine KK Women's &amp; Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biju","family":"Thomas","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School National University of Singapore  Singapore"},{"name":"Pediatric Respiratory Medicine KK Women's &amp; Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-4217","authenticated-orcid":false,"given":"Jan Hau","family":"Lee","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010NUS Medical School National University of Singapore  Singapore"},{"name":"Children's Intensive Care Unit KK Women's &amp; Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-992X","authenticated-orcid":false,"given":"Anuradha P.","family":"Menon","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010NUS Medical School National University of Singapore  Singapore"},{"name":"Children's Intensive Care Unit KK Women's &amp; 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