{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:22:26Z","timestamp":1778286146826,"version":"3.51.4"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The common side effects of COVID\u201019 vaccination were mostly self\u2010restricted local reactions that quickly resolved. Nevertheless, rare autoimmune hepatitis cases have been reported in some vaccinated with mRNA COVID\u201019 vaccines. This article presents a young man who developed fulminant hepatitis a few days after vaccination with the first dose of the AstraZeneca COVID\u201019 vaccine. A 35\u2010year\u2010old man was admitted to our hospital with generalized weakness, abdominal pain, and jaundice. He received the first dose of the AstraZeneca COVID\u201019 vaccine 8\u2009days earlier. He was admitted to the hospital with a chief complaint of abdominal pain. On admission and because of his high D\u2010dimers, low platelet count, and low Fibrinogen level, vaccine\u2010induced immune thrombosis thrombocytopenia was suspected, which was ruled out later. Then, after a surge in his liver function tests, decreasing platelet, and abnormal clotting tests, fulminant hepatitis was considered for this patient. Several bacterial, viral, and autoimmune etiologies were then suspected, with all ruled out. Thus, fulminant hepatitis secondary to his AstraZeneca COVID\u201019 vaccine was confirmed. Unfortunately, he died 3\u2009days later of disseminated intravascular coagulopathy, after which a liver necropsy was performed, indicating drug\/toxin\u2010induced hepatitis.<\/jats:p>","DOI":"10.1002\/ccr3.6066","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T09:54:05Z","timestamp":1658224445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fulminant hepatitis following\n                    <scp>COVID<\/scp>\n                    \u201019 vaccination: A\u00a0case report"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8733-9370","authenticated-orcid":false,"given":"Mohammad","family":"Barary","sequence":"first","affiliation":[{"name":"Student Research Committee, Virtual School of Medical Education and Management Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center (SSRC) Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-9741","authenticated-orcid":false,"given":"Athena","family":"Sharifi\u2010Razavi","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit of Bou\u2010Ali Sina Hospital Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-4849","authenticated-orcid":false,"given":"Nasser","family":"Rakhshani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gastrointestinal and Liver Diseases Research Centre, Firoozgar Hospital Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4210-5479","authenticated-orcid":false,"given":"Terence T.","family":"Sio","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-0448","authenticated-orcid":false,"given":"Soheil","family":"Ebrahimpour","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-9682","authenticated-orcid":false,"given":"Mana","family":"Baziboroun","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"Exacerbating Guillain\u2013Barr\u00e9 syndrome eight days after vector\u2010based COVID\u201019 vaccination","volume":"2021","author":"Finsterer J","year":"2021","journal-title":"Case Rep Infect Dis"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0142"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102662"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.6066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.6066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.6066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:03:49Z","timestamp":1764306229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.6066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/ccr3.6066"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.6066","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2022-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6066"}}