{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:50:52Z","timestamp":1772081452915,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Klippel\u2013Tr\u00e9naunay syndrome (KTS) is a rare congenital disorder defined by a triad of capillary malformation, venous malformation, and soft tissue or bone hypertrophy most commonly affecting unilateral lower limbs. Due to the rarity of KTS, evidence\u2010based guidelines for the management of pregnancy in people with KTS are still lacking. A 34\u2010year\u2010old woman (gravidity 1; parity 0) presented at 25\u2009weeks of gestation with malformations of the right side of her body. The extent of the KTS affecting the vulva, pelvis, and right leg was remarkable. As the prenatal MRI showed massive vascular malformations of the pelvis and vulva, we performed an elective cesarean section to avoid severe perinatal hemorrhage during a vaginal delivery. Intraoperatively, we observed varices on the parietal peritoneum within the vesico\u2010uterine pouch and the isthmocervical transition of the uterus, which were not identifiable in the preoperative MRI. Although KTS patients have been discouraged from pregnancy in the past because of a high risk for complications, successful and uncomplicated pregnancies are possible. For this purpose, we believe a multidisciplinary strategy that is crucial.<\/jats:p>","DOI":"10.1002\/ccr3.6130","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T04:06:36Z","timestamp":1658721996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy management for a woman with extensive vulvar and pelvic malformations caused by Klippel\u2013Tr\u00e9naunay syndrome"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4099-1596","authenticated-orcid":false,"given":"Konstantin","family":"Hofmann","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Macchiella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Kloeckner","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Hasenburg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"StatPearls","author":"Naganathan S","year":"2021"},{"issue":"5","key":"e_1_2_10_3_1","first-page":"e8023","article-title":"Presentation and Management of Klippel\u2010Trenaunay Syndrome: a review of available data","volume":"12","author":"Asghar F","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000812"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3673"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvir.2019.100634"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018378"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14698"},{"issue":"5","key":"e_1_2_10_10_1","first-page":"246","article-title":"Venous thromboembolism and prothrombotic parameters in Klippel\u2010Trenaunay syndrome","volume":"71","author":"Oduber CEU","year":"2013","journal-title":"Neth J Med"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019156"},{"key":"e_1_2_10_12_1","first-page":"4328450","article-title":"Diffuse venous malformation of the uterus in a pregnant woman with Klippel\u2010Tr\u00e9naunay syndrome diagnosed by DCE\u2010MRI","volume":"2016","author":"Yara N","year":"2016","journal-title":"Case Rep Obstet Gynecol"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019932"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6583562"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X17719181"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.6130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.6130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.6130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:02:56Z","timestamp":1764306176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.6130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/ccr3.6130"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.6130","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2022-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6130"}}