{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T18:41:38Z","timestamp":1773513698245,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Papillary thyroid carcinoma is the most common type of thyroid cancer and accounts for almost 89.4% of all thyroid carcinomas. Hodgkin lymphoma is a heterogeneous group of neoplasms and represents 10% of lymphomas. These two cancers do not share the same risk factors. Some studies have reported the association of thyroid papillary carcinoma with lymphomas, mainly Hodgkin's lymphoma, treated with radiotherapy. However, to our knowledge less than 10 cases have illustrated synchronous papillary thyroid carcinoma and Hodgkin lymphoma with no history of radiotherapy. We present the case of a 49\u2010year\u2010old female patient, with no history of past exposure to radiation, who was incidentally diagnosed with Hodgkin lymphoma during the work up for papillary thyroid carcinoma. Our patient had total thyro\u00efdectomy with cervical lymphadenectomy. The histopathologic examination concluded to a papillary thyroid carcinoma of classical variant. And the lymph node dissection enabled us to diagnose not only papillary thyroid carcinoma's lymph node metastasis, but also Hodgkin Lymphoma. This discovery of the Hodgkin lymphoma was totally incidental. The discovery of synchronous tumors in patients with papillary thyroid carcinoma has been reported in the literature. However, the diagnosis of Hodgkin through lymph node dissection for papillary thyroid carcinoma is extremely rare. This underlines the singularity and the importance of our case. The synchronous papillary thyroid carcinoma and Hodgkin lymphoma is a rare condition, which may pose significant diagnostic and treatment dilemmas. To date, there is no standardized approach due to lack of experience. The molecular mechanisms of this link are poorly understood and yet remain to be elucidated.<\/jats:p>","DOI":"10.1002\/ccr3.6246","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T12:58:56Z","timestamp":1660049936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidental discovery of a Hodgkin lymphoma synchronous to a papillary thyroid carcinoma"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-0888","authenticated-orcid":false,"given":"Maissa","family":"Ben Thayer","sequence":"first","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis El Manar University  Tunis Tunisia"},{"name":"Depatment of Pathology Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Khanchel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis El Manar University  Tunis Tunisia"},{"name":"Depatment of Pathology Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imen","family":"Helal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis El Manar University  Tunis Tunisia"},{"name":"Depatment of Pathology Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorra","family":"Chiboub","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis El Manar University  Tunis Tunisia"},{"name":"Department of Otorhinolaryngology\u2010Head and neck surgery Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2383-365X","authenticated-orcid":false,"given":"Khouloud","family":"Ben Lazreg","sequence":"additional","affiliation":[{"name":"Depatment of Pathology Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raweh","family":"Hedhli","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis El Manar University  Tunis Tunisia"},{"name":"Depatment of Pathology Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsen","family":"Ben Brahim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis El Manar University  Tunis Tunisia"},{"name":"Depatment of Pathology Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Jouini","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis El Manar University  Tunis Tunisia"},{"name":"Depatment of Pathology Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aschraf","family":"Cheddli\u2010Debbich","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis El Manar University  Tunis Tunisia"},{"name":"Depatment of Pathology Habib Thameur's Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4236\/ijohns.2021.103019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.11106\/cet.2014.7.2.129"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/endoabs.67.GP9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841867809128248"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.175560"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.18.2164"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0171"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1154"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122958"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"337","article-title":"Second primary cancer in patients with papillary thyroid carcinoma","volume":"33","author":"Zafon C","year":"2013","journal-title":"Anticancer Res"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108293250902"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481007601147"},{"key":"e_1_2_10_15_1","unstructured":"34e Congr\u00e8s de la Soci\u00e9t\u00e9 Fran\u00e7aise d'Endocrinologie \u2010 du 11 au 14 octobre 2017 Poitiers | [Internet]. Accessed July 25 2022.https:\/\/www.congres\u2010sfe.com\/2017\/getabstract!fr!!!!33bda641\u201039b7\u201011e7\u2010a5f1\u2010e8c2100b0703"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.15761\/OHNS.1000228"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2014.10.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.07.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2017.01.020"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.humpath.2003.07.001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136058"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00312"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1079"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.6246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.6246","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.6246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:53:19Z","timestamp":1692669199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.6246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/ccr3.6246"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.6246","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"2022-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6246"}}