{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:59:34Z","timestamp":1768737574147,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Serotonin syndrome is a potentially life\u2010threatening adverse drug reaction typically caused by a single or combination of two or more medications with serotonergic properties due to increased serotonin release. Our case is a 60\u2010year\u2010old drug\u2010addict man who was admitted to the poisoning department of Loghman hospital with methadone poisoning. On the fifth day of hospitalization and after initiating the linezolid treatment for VAP, the patient began to run a fever with agitation, tremor, spontaneous clonus movement in the hands, and tachycardia. Due to patients' manifestations and after ruling out other diagnoses, serotonin syndrome was confirmed with the possibility of concomitant use of linezolid and methadone. Linezolid administration was promptly discontinued, and vancomycin therapy was initiated (1000\u2009mg twice a day intravenously). Supportive therapies were performed. Finally, tremor, rigidity, and clonus movement disappeared within 48\u2009h.<\/jats:p>","DOI":"10.1002\/ccr3.6341","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T01:33:20Z","timestamp":1667698400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serotonin syndrome due to concomitant use of linezolid and methadone"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-3642","authenticated-orcid":false,"given":"Farnoosh","family":"Masbough","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheil","family":"Roshanzamiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Clinical Toxicology, Toxicology Research Center, Excellence Center of Clinical Toxicology, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Sahraei","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyman Erfan Talab","family":"Evini","sequence":"additional","affiliation":[{"name":"Department of Clinical Toxicology, Toxicology Research Center, Excellence Center of Clinical Toxicology, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-42-2-417"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"533","article-title":"Serotonin syndrome","volume":"13","author":"Volpi\u2010Abadie J","year":"2013","journal-title":"Ochsner J"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-018-2244-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2017169"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/503839"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.09r00853"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"263","article-title":"Serotonin syndrome due to co\u2010administration of linezolid and methadone","volume":"25","author":"Mastroianni A","year":"2017","journal-title":"Infez 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