{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:16:49Z","timestamp":1772709409310,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Graves' disease is characterized by the presence of circulating autoantibodies that stimulate the TSH receptor, inducing hyperthyroidism and goiter. Hashimoto's thyroiditis is an autoimmune disease leading to thyroid tissue destruction by cell and antibody\u2010mediated immune processes. The occurrence of Hashimoto's thyroiditis following Graves' disease has been rarely reported. Its pathogenesis is not clear. Herein, we report the case of a 40\u2010year\u2010old woman who was referred to our department for thyrotoxicosis. Laboratory tests revealed overt hyperthyroidism. Thyroid scintigraphy showed an enlarged gland with diffusely increased tracer uptake, confirming the diagnosis of Graves's disease. The patient was treated with propranolol and thiamazole. Two months later, she received radioactive iodine therapy. Three years and 9\u00a0months later, the patient presented with hypothyroidism and very high levels of thyroperoxidase antibodies consistent with the diagnosis of Hashimoto's thyroiditis. She was treated with levothyroxine. The shift from Graves' disease to Hashimoto's thyroiditis was reported in the literature. However, its pathogenesis has not been clearly elucidated.<\/jats:p>","DOI":"10.1002\/ccr3.6466","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T13:16:19Z","timestamp":1665666979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A case of Hashimoto's thyroiditis following Graves' disease"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4278-9447","authenticated-orcid":false,"given":"Ibtissem","family":"Oueslati","sequence":"first","affiliation":[{"name":"Department of Endocrinology La Rabta University Hospital, University of Tunis\u2010El Manar, Faculty of Medicine  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Salhi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology La Rabta University Hospital, University of Tunis\u2010El Manar, Faculty of Medicine  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-5229","authenticated-orcid":false,"given":"Meriem","family":"Yazidi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology La Rabta University Hospital, University of Tunis\u2010El Manar, Faculty of Medicine  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Chaker","sequence":"additional","affiliation":[{"name":"Department of Endocrinology La Rabta University Hospital, University of Tunis\u2010El Manar, Faculty of Medicine  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-9885","authenticated-orcid":false,"given":"Melika","family":"Chihaoui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology La Rabta University Hospital, University of Tunis\u2010El Manar, Faculty of Medicine  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.013"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1024"},{"key":"e_1_2_12_4_1","first-page":"2055","volume-title":"Endocrinology","author":"Amino N","year":"2006"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"31","article-title":"Hashimoto's thyroiditis following Graves' disease","volume":"42","author":"Umar H","year":"2010","journal-title":"Acta Med Indones"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2019.34.1.29"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-018-0322-7"},{"issue":"1","key":"e_1_2_12_8_1","first-page":"25","article-title":"Radioiodine I\u2010131 for the therapy of Graves' disease","volume":"16","author":"Mumtaz M","year":"2009","journal-title":"Malays J 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