{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T20:09:11Z","timestamp":1769458151639,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lutembacher syndrome (LS) is a rare heart disorder characterized by a congenital or acquired combination of the atrial septal defect (ASD) and mitral stenosis. In LS, patients may be asymptomatic for years, but early detection and treatment result in a better prognosis. In contrast, the prognosis is usually poor, with conservative treatment if the diagnosis is late and the patient develops heart failure and pulmonary hypertension. Although rheumatic heart disease (RHD) and congenital heart disease are prevalent in Ghana, cases of LS are not reported. Here, we report the case of a 45\u2010year\u2010old woman with rheumatic mitral valve stenosis and an exceptionally large ASD with bidirectional flow who was diagnosed with LS and treated conservatively for heart failure at a cardiology clinic in Ghana.<\/jats:p>","DOI":"10.1002\/ccr3.6939","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T15:30:34Z","timestamp":1676043034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lutembacher syndrome in a middle\u2010aged woman in Ghana with an extremely large atrial septal defect"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1567-5786","authenticated-orcid":false,"given":"Yaw","family":"Adu\u2010Boakye","sequence":"first","affiliation":[{"name":"Department of Medicine Kwame Nkrumah University of Science and Technology  Kumasi Ghana"},{"name":"Department of Medicine Komfo Anokye Teaching Hospital  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-6290","authenticated-orcid":false,"given":"Gordon Manu","family":"Amponsah","sequence":"additional","affiliation":[{"name":"Department of Medicine Komfo Anokye Teaching Hospital  Kumasi Ghana"},{"name":"Department of Physiology Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry Kofi","family":"Andoh","sequence":"additional","affiliation":[{"name":"Department of Medicine Komfo Anokye Teaching Hospital  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-4961","authenticated-orcid":false,"given":"Kwadwo Faka","family":"Gyan","sequence":"additional","affiliation":[{"name":"Department of Medicine Komfo Anokye Teaching Hospital  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-0577","authenticated-orcid":false,"given":"Yaw Amo","family":"Wiafe","sequence":"additional","affiliation":[{"name":"Department of Medicine Komfo Anokye Teaching Hospital  Kumasi Ghana"},{"name":"Department of Medical Diagnostics Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2016.07.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320530113"},{"key":"e_1_2_11_4_1","first-page":"237","article-title":"De la st\u00e9nose mitrale avec communication interauriculaire","volume":"9","author":"Lutembacher R","year":"1916","journal-title":"Arch mal 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