{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:55:42Z","timestamp":1791896142243,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an open pilot trial, six patients with various hereditary forms of spinocerebellar ataxia (SCA) were assigned to topiramate (50\u2009mg\/day) for 24\u2009weeks. Four patients completed the protocol without adverse events. Of these four patients, topiramate was effective for three patients. Some patients with SCA could respond to treatment with topiramate.<\/jats:p>","DOI":"10.1002\/ccr3.6980","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T13:33:12Z","timestamp":1677418392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A trial of topiramate for patients with hereditary spinocerebellar ataxia"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2409-8404","authenticated-orcid":false,"given":"Shiroh","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Neurology and Geriatric Medicine Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Kita\u2010ku Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yorita","sequence":"additional","affiliation":[{"name":"Division of Respirology, Neurology and Rheumatology, Department of Medicine Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kida","sequence":"additional","affiliation":[{"name":"Department of Anatomy Fukuoka University School of Medicine  Jonan\u2010ku Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Neurology Fukuoka Sanno Hospital  Sawara\u2010ku Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yamanishi","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology  Iizuka Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.28"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12341"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1468"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/448645a"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.03.004"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132939"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000138107"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001318"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.103"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.26"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028025"},{"key":"e_1_2_12_13_1","first-page":"30","article-title":"Drug repositioning: a machine\u2010learning approach through data integration","volume":"5","author":"Napolitano F","year":"2013","journal-title":"J Chem"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci500670q"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00330"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00231-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2018.07.005"},{"key":"e_1_2_12_18_1","first-page":"11","article-title":"A novel missense variation (E308D) of SPTBN2 in a Japanese patient with cerebellar ataxia","volume":"35","author":"Fujioka R","year":"2016","journal-title":"Bulletin of Beppu Univ JC"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00543-0"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2010.46.4.1445795"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00405.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271897"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181f84a39"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2012.08.006"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515974"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.6980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.6980","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.6980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:44:56Z","timestamp":1692625496000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.6980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/ccr3.6980"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.6980","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2022-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6980"}}