{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:50:56Z","timestamp":1754146256070,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Intrathecal methotrexate can cause cauda equina syndrome in pediatric ALL patients, as demonstrated in this rare case of an 8\u2010year\u2010old boy. Symptoms included progressive limb weakness and urinary retention. Early recognition, prompt discontinuation of the offending agent, and multidisciplinary management are crucial. Vigilant neurological monitoring is essential for pediatric acute lymphoblastic leukemia patients receiving intrathecal chemotherapy.<\/jats:p>","DOI":"10.1002\/ccr3.70122","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T08:40:31Z","timestamp":1737016831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Induced Cauda Equina Syndrome in an 8\u2010Year\u2010Old Boy With Acute Lymphoblastic Leukemia: An Uncommon Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Marzieh","family":"Babaee","sequence":"first","affiliation":[{"name":"Physical Medicine and Rehabilitation Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Javadzadeh","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Pediatric Neurology Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2103-7827","authenticated-orcid":false,"given":"Ali","family":"Hazeghi","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Pediatric Neurology Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25672"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4047617"},{"issue":"4","key":"e_1_2_13_4_1","first-page":"9","article-title":"What Is the Next Step After an Electrodiagnostic Study in Children With Polyneuropathies? Rationale for Laboratory and Other Diagnostic Tests","volume":"17","author":"Babaee M.","year":"2023","journal-title":"Iranian Journal of Child Neurology"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.IJC_422_19"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2013.37.3.420"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0645-y"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23830"},{"issue":"9","key":"e_1_2_13_9_1","first-page":"2502","article-title":"Methotrexate Neurotoxicity: In\u00a0Vitro Studies Using Cerebellar Explants From Rats","volume":"49","author":"Gilbert M. R.","year":"1989","journal-title":"Cancer Research"},{"key":"e_1_2_13_10_1","doi-asserted-by":"crossref","unstructured":"S.Motz A.Jamal H.Imran et\u00a0al. \u201cMethotrexate Induced Central Nervous System Manifestations in Children Receiving Treatment for Acute Lymphoid Malignancies \u201d142(2023):5810.","DOI":"10.1182\/blood-2023-190820"},{"issue":"9","key":"e_1_2_13_11_1","first-page":"1887","article-title":"Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings","volume":"24","author":"Sandoval C.","year":"2003","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21764"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2026"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-015-1727-z"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010290057336"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.53.0808"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T03:21:16Z","timestamp":1752808876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ccr3.70122"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70122","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70122"}}